Chiral Macroporous MOF Surfaces for Electroassisted Enantioselective Adsorption and Separation

Abstract

The development of surfaces with chiral features is a fascinating challenge for modern material science, especially when they are used for chiral separation technologies. In this contribution, the design of hierarchically structured chiral macroporous ZIF-8 electrodes is presented. They are elaborated by an electrochemical depositiondissolution technique, based on the electrodeposition of metal through a colloidal crystal template, followed by controlled electrooxidation. This generates locally metal cations, which can interact with a chiral ligand present in solution to form Metal-Organic Frameworks (MOFs). The macroporous structure facilitates the access of the chiral recognition sites, located in the mesoporous MOF and thus helps to overcome mass transport limitations. The efficiency of the designed functional materials for chiral adsorption and separation can be fine-tuned by applying an adjustable electric potential to the electrode surfaces. This hierarchical chiral ZIF-8 structure was deposited at the walls of a microfluidic device and used as a stationary phase for enantioselective separation. The potential-controlled interaction between the stationary phase and the chiral analytes allows baseline separation of two enantiomers. This opens up interesting perspectives for using hierarchically structured chiral MOF as an efficient material for the selective adsorption and separation of chiral compounds.

Electrochemical Synthesis Methods of Metal‐Organic Frameworks and Their Environmental Analysis Applications: A Review

“…In recent years, a considerable number of researchers have been committed to improving ADS for developing new MOF crystals by the replacement of substrate, [44][45] the employment of additional templates [46][47] and adding structure-directing agents. [48] Moreover, ADS has greatly helped to innovate the synthesis of MOFs (as well as their complexes) and broaden their practical applications.…”

Metal‐Organic Frameworks as a New Platform for Enantioselective Separations

“…The potential difference between chiral analyte and stationary phase gave a baseline separation of the enantiomers. [74] Homochiral MOF grown on hydroxyl and carboxyl substrates gave homochiral porous MOF thin films (SUR-MOF) [Cu 2 (D-cam) 2 L 13 ] n (L 13 = dabco or bpy). When hydroxy group with MUD (11-mercaptoundecanol) and carboxyl group with MHDA (16-mercaptohexadecanoic acid) were selected, the chiral-SURMOF showed its preferential growth along [001] and [110] orientation.…”

ATP-responsive near-infrared fluorescent nanoparticles for synergistic chemotherapy and starvation therapy

“…Metal-organic frameworks (MOFs) are a class of ordered porous materials formed by the precise coordination of organic ligands and metal ions/clusters. [25][26][27] They have the advantages of convenient preparation, an adjustable structure, versatility and good biological compatibility, and can be used in the field of sensing, 28,29 photocatalysis, 30 gas adsorption/ separation [31][32][33] and biomedicine. 34,35 Among them, special efforts have been devoted to the use of MOFs for controlled drug delivery systems.…”