Children with developmental coordination disorder show altered functional connectivity compared to peers

Rinat, Shie; Izadi‐Najafabadi, Sara; Zwicker, Jill G.

doi:10.1016/j.nicl.2020.102309

Cited by 23 publications

(22 citation statements)

References 145 publications

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“…We showed that the CO-OP intervention reverted this pattern in children with DCD. Similar to our resting state results (Rinat et al, 2020 ), children with DCD + ADHD did not show any brain changes after the CO-OP intervention.…”

Section: Discussionsupporting

confidence: 92%

“…Moreover, CO-OP intervention induces structural changes in other DMN white matter tracts, including the corona radiata (Izadi-Najafabadi et al, 2020). Based on our results from DTI analysis and other analysis (Izadi-Najafabadi et al, 2020;Rinat et al, 2020), we infer that the CO-OP intervention improves both functional and structural connectivity of the DMN, which is responsible for attention-and self-regulation (Shamloo and Helie, 2016;Reddy et al, 2018;Izadi-Najafabadi et al, 2020). We have previously suggested that these functions are implicated in children with DCD due to altered connectivity between the posterior cingulate cortex and DMN (Rinat et al, 2020).…”

Section: Attention and Self-regulationmentioning

confidence: 64%

“…The CO-OP intervention uses a global strategy of Goal-Plan-Do-Check where children set goals and motivate themselves, perform the task, observe their own performance, judge it to improve it, and then achieve their goal and express their self-satisfaction (Polatajko and Mandich, 2004), which is similar to the three phases of self-regulation (i.e., forethought, performance, and self-reflection) based on Triadic Model of Self-regulation (Zimmerman, 2000). We have also shown that CO-OP intervention induces both increased FA in white matter structures underlying the DMN and increased functional connectivity between the DMN and the anterior cingulate cortex in this population (Rinat et al, 2020). High functional connectivity between regions of the DMN is related to their increased structural connectivity (van den Heuvel et al, 2008;Damoiseaux and Greicius, 2009), in particular, increased FA in the right and left cingulum (Bathelt et al, 2019).…”

Section: Attention and Self-regulationmentioning

confidence: 73%

“…We have also shown that CO-OP intervention induces both increased FA in white matter structures underlying the DMN and increased functional connectivity between the DMN and the anterior cingulate cortex in this population (Rinat et al, 2020 ). High functional connectivity between regions of the DMN is related to their increased structural connectivity (van den Heuvel et al, 2008 ; Damoiseaux and Greicius, 2009 ), in particular, increased FA in the right and left cingulum (Bathelt et al, 2019 ).…”

Section: Discussionmentioning

confidence: 89%

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White Matter Changes With Rehabilitation in Children With Developmental Coordination Disorder: A Randomized Controlled Trial

Izadi‐Najafabadi

Zwicker

2021

Front. Hum. Neurosci.

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Background and Objectives: Children with developmental coordination disorder (DCD) have difficulty learning motor skills, which can affect their participation in activities of daily living and psychosocial well-being. Over 50% of children with DCD also have attention deficit hyperactivity disorder (ADHD), which further exacerbates their motor problems and impact on quality of life. A rehabilitation approach known as Cognitive Orientation to Occupational Performance uses problem-solving strategies to help children learn motor skills they wish to achieve. While this cognitive approach has been effective for children with DCD, few studies have examined the effectiveness of this approach for children with co-occurring ADHD. Further, the underlying mechanism and neural basis of this intervention are largely unknown.Methods: In this randomized waitlist-controlled trial, we used MRI to examine white matter microstructure after intervention in 8–12-year-old children with DCD (n = 28) and with DCD and co-occurring ADHD (n = 25). Children in both groups were randomized to either a treatment group or waitlist group at their first MRI. The treatment group began the intervention after their MRI scan and returned for a post-treatment scan at 3 months, and follow-up scan at 6 months; the waitlist group waited 3 months before their second MRI, received the intervention, and then had a post-treatment scan. Each child received intervention once weekly for 10 weeks. Diffusion tensor imaging was used to acquire white matter diffusion parameters and was analyzed using tract-based spatial statistics (TBSS).Results and Conclusion: Children with DCD showed significant improvement in white matter microstructure in the bilateral anterior thalamic radiation, bilateral sensorimotor tract, bilateral cingulum, fornix, splenium and body of corpus callosum, right inferior fronto-occipital fasciculus, and white matter pathways to bilateral inferior gyri, right middle frontal gyrus, frontal medial cortex, and left cuneus. We suggest that these rehabilitation-induced neural changes in children with DCD occurred in regions associated with attention, self-regulation, motor planning, and inter-hemispheric communication, which positively affected brain connectivity and motor function. In contrast, children with DCD and co-occurring ADHD did not show any brain changes following the intervention. Modifications to the treatment protocol might help address the attentional and self-regulatory needs of children with a dual diagnosis.Clinical Trial Registration: ClinicalTrials.gov ID: NCT02597751.

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Section: Discussionsupporting

confidence: 92%

Section: Attention and Self-regulationmentioning

confidence: 64%

Section: Attention and Self-regulationmentioning

confidence: 73%

Section: Discussionmentioning

confidence: 89%

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White Matter Changes With Rehabilitation in Children With Developmental Coordination Disorder: A Randomized Controlled Trial

Izadi‐Najafabadi

Zwicker

2021

Front. Hum. Neurosci.

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“…However, in children with DCD, no strong intrahemispheric connections with the motor cortex were found in the right putamen, which was equally well-connected to the left and right SM1 (McLeod et al, 2016). Also, Rinat et al (2020) showed that the connection between bilateral SM1 and posterior cingulate cortex (PCC; BA23, BA31) and precuneus (BA7, BA31), SM1 and left posterior middle temporal gyrus (pMTG) was weaker in children with DCD than that in children with TD.…”

Section: Connectivitymentioning

confidence: 95%

Neural Basis and Motor Imagery Intervention Methodology Based on Neuroimaging Studies in Children With Developmental Coordination Disorders: A Review

Irie

Matsumoto

Zhao

et al. 2021

Front. Hum. Neurosci.

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Although the neural bases of the brain associated with movement disorders in children with developmental coordination disorder (DCD) are becoming clearer, the information is not sufficient because of the lack of extensive brain function research. Therefore, it is controversial about effective intervention methods focusing on brain function. One of the rehabilitation techniques for movement disorders involves intervention using motor imagery (MI). MI is often used for movement disorders, but most studies involve adults and healthy children, and the MI method for children with DCD has not been studied in detail. Therefore, a review was conducted to clarify the neuroscientific basis of the methodology of intervention using MI for children with DCD. The neuroimaging review included 20 magnetic resonance imaging studies, and the neurorehabilitation review included four MI intervention studies. In addition to previously reported neural bases, our results indicate decreased activity of the bilateral thalamus, decreased connectivity of the sensory-motor cortex and the left posterior middle temporal gyrus, bilateral posterior cingulate cortex, precuneus, cerebellum, and basal ganglia, loss of connectivity superiority in the abovementioned areas. Furthermore, reduction of gray matter volume in the right superior frontal gyrus and middle frontal gyrus, lower fractional anisotropy, and axial diffusivity in regions of white matter pathways were found in DCD. As a result of the review, children with DCD had less activation of the left brain, especially those with mirror neurons system (MNS) and sensory integration functions. On the contrary, the area important for the visual space processing of the right brain was activated. Regarding of characteristic of the MI methods was that children observed a video related to motor skills before the intervention. Also, they performed visual-motor tasks before MI training sessions. Adding action observation during MI activates the MNS, and performing visual-motor tasks activates the basal ganglia. These methods may improve the deactivated brain regions of children with DCD and may be useful as conditioning before starting training. Furthermore, we propose a process for sharing the contents of MI with the therapist in language and determining exercise strategies.

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Developmental Coordination Disorder

Wasserman¹,

Wasserman²

2023

Apraxia: The Neural Network Model

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Children with developmental coordination disorder show altered functional connectivity compared to peers

Cited by 23 publications

References 145 publications

White Matter Changes With Rehabilitation in Children With Developmental Coordination Disorder: A Randomized Controlled Trial

White Matter Changes With Rehabilitation in Children With Developmental Coordination Disorder: A Randomized Controlled Trial

Neural Basis and Motor Imagery Intervention Methodology Based on Neuroimaging Studies in Children With Developmental Coordination Disorders: A Review

Developmental Coordination Disorder

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