Children born after assisted fertilization have an increased rate of major congenital anomalies

Klemetti, Reija; Gissler, Mika; Sevón, Tiina; Koivurova, Sari; Ritvanen, Annukka; Hemminki, Elina

doi:10.1016/j.fertnstert.2005.03.085

Cited by 167 publications

(110 citation statements)

References 23 publications

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“…This is higher than other reports because our study was restricted to women who were trying to become pregnant, rather than the entire birth population (2). We confirmed the previously reported relationship that singleton infants born to mothers who undergo ART procedures are more likely to be low birthweight (11)(12)(13)(14)(15), preterm (13,14,30), or SGA (13,30,31) than singleton infants born to mothers who did not undergo treatment. We further provide one of a few studies of this size and diversity showing an association between the use of ovulation stimulation medications without ART and infants being born small for gestational age for singleton infants.…”

Section: Discussionsupporting

confidence: 91%

“…Some studies have also found a greater risk of birth defects among singletons and multiples conceived using ART compared with those conceived without treatment (15)(16)(17)(18); however, the evidence is inconsistent and suggests that risk may be related to underlying infertility (19)(20)(21). Concern about long-term sequelae of ART use, such as neurodevelopmental problems, has been identified as an area needing further research (22)(23)(24)(25).…”

mentioning

confidence: 99%

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Birth outcomes of intended pregnancies among women who used assisted reproductive technology, ovulation stimulation, or no treatment

D’Angelo

Whitehead

Helms

et al. 2011

Fertility and Sterility

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Section: Discussionsupporting

confidence: 91%

mentioning

confidence: 99%

Birth outcomes of intended pregnancies among women who used assisted reproductive technology, ovulation stimulation, or no treatment

D’Angelo

Whitehead

Helms

et al. 2011

Fertility and Sterility

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“…The majorities of these newborns are healthy and develop well. However, some studies report poorer birth outcomes and a higher risk of certain types of birth defects for infants born as a result of assisted fertilization than for infants conceived naturally [8,24,31].…”

Section: Introductionmentioning

confidence: 99%

Effect of sperm entry on blastocyst development after in vitro fertilization and intracytoplasmic sperm injection — mouse model

Piotrowska-Nitsche

Chan

2012

J Assist Reprod Genet

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Purpose To investigate whether in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI), influence the embryo's development and its quality using the mouse as a model. Methods Assisted fertilization was performed using ICSI and IVF. Fluorescent beads were adhered to the fertilization cone or place of previous sperm injection in the natural mated (NM), IVF and ICSI embryos, respectively. Embryo examination was carried out at the two-cell and blastocyst stage to determine the position of fluorescent bead. Protein expression was detected by fluorescence immunocytochemical staining and confocal microscopic imaging of blastocysts. Results IVF and ICSI embryos developed at rates comparable to NM group. Embryos show similar expression patterns of two transcription factors, Oct4 and Cdx2. The most preferred place for spermatozoa attachment was the equatorial site of the egg, whether fertilization occurred in vitro or under natural conditions. We also link the sperm entry position (SEP) to embryo morphology and the number of cells at the blastocyst stage, with no influence of the method of fertilization. Conclusions IVF and ICSI, do not compromise in vitro preimplantation development. Additional data, related to sperm entry, could offer further criteria to predict embryos that will implant successfully. Based on embryo morphology, developmental rate and protein expression level of key transcription factors, our results support the view that ART techniques, such as IVF and ICSI, do not perturb embryonic development or quality.

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“…34,35 Studies also have suggested that assisted reproduction could be a risk factor for chromosomal abnormalities like DS. 36,37 To our knowledge, this analysis is the first to explore reproductive factors in children with DS and the risk of leukemia.…”

mentioning

confidence: 99%

Reproductive history, infertility treatment, and the risk of acute leukemia in children with down syndrome

Puumala

Ross

Olshan

et al. 2007

Cancer

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Background: Distal conduit obstruction is a recognized complication after surgery for congenital heart disease requiring implantation of a conduit from the right ventricle to the pulmonary arteries. Endovascular stenting of distal conduit obstruction can be challenging due to the proximity to the pulmonary artery bifurcation. Objective: A technique is described, whereby a single stent is mounted onto two balloon angioplasty catheters in tandem. This ensemble was delivered to the distal conduit/pulmonary artery via a large Mullins sheath on two guidewires, one placed in each of the branch pulmonary arteries. The aim was to assess safety and efficacy of this novel technique. Materials and Results: Seven patients (mean age 13.4 (6.7–23.4) years, mean weight 44.2 (23–69) kg were treated with this method. The pressure gradient was reduced from 36 (26–52) mm Hg to 11 (8–15) mm Hg [P< 0.05]. RV/LV pressure ratio decreased from 0.85 (0.6–0.95) to 0.42 (0.35–0.5) [P < 0.05]. There were no significant complications. During follow‐up over a median of 2.6 (0.3–6.7) years no patient required re‐intervention or surgery. Conclusion: This novel technique appears to be safe and effective for stenting stenoses just proximal to pulmonary artery bifurcation. © 2011 Wiley‐Liss, Inc.

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Children born after assisted fertilization have an increased rate of major congenital anomalies

Cited by 167 publications

References 23 publications

Birth outcomes of intended pregnancies among women who used assisted reproductive technology, ovulation stimulation, or no treatment

Birth outcomes of intended pregnancies among women who used assisted reproductive technology, ovulation stimulation, or no treatment

Effect of sperm entry on blastocyst development after in vitro fertilization and intracytoplasmic sperm injection — mouse model

Reproductive history, infertility treatment, and the risk of acute leukemia in children with down syndrome

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