Childhood Vaccination and Nontargeted Infectious Disease Hospitalization

Abstract

These results do not support the hypotheses that multiple-antigen vaccines or aggregated vaccine exposure increase the risk of nontargeted infectious disease hospitalization.

Live Vaccine Against Measles, Mumps, and Rubella and the Risk of Hospital Admissions for Nontargeted Infections

“…In high-income countries, some studies also found an association with MMR and lower risk of infectious diseases. [30][31][32] However, these studies have not focused on the most recently administered vaccine and are therefore not directly comparable with the present study. It has been a consistent observation in low-income countries that the most recent vaccination most strongly influences susceptibility to unrelated infections.…”

Association Between Estimated Cumulative Vaccine Antigen Exposure Through the First 23 Months of Life and Non–Vaccine-Targeted Infections From 24 Through 47 Months of Age

“…A Danish cohort study using national registry data for children born between 1990 and 2001 examined the association between 7 childhood vaccinations and nontargeted infectious diseases in children younger than age 5 years. 7 The study did not find evidence that multiple vaccine exposure was associated with the risk for nontargeted infectious diseases. Despite using a different population, study period, study design, and method of defining the exposure, this current nested case-control study arrived at the same conclusion.…”

“…A Danish cohort study using national registry data for children born between 1990 and 2001 examined the association between 7 childhood vaccinations and nontargeted infectious diseases in children younger than age 5 years . The study did not find evidence that multiple vaccine exposure was associated with the risk for nontargeted infectious diseases.…”

“…This hypothesis was tested in a Danish cohort of children born between 1990 and 2001. Examining a childhood schedule that included 5 vaccines against 7 diseases, the study did not find evidence that multiple antigen exposure was associated with the risk for non–vaccine-targeted infectious diseases …”

Vaccine safety issues at the turn of the 21st century

“…A US study evaluated live vaccines compared with inactivated vaccines as the latest vaccine given and observed a reduced risk of IDH, following a live vaccine compared with an inactivated vaccine 75. These results are in contrast to another Danish study which did not report any increased risks of IDH after different inactivated vaccines including whole-cell pertussis vaccine, a Dutch study reporting a protective effect on IDH of receiving a fourth DTaP vaccine compared with three, and a self-controlled case series study from England reporting no increased risk of IDH for children receiving MMR vaccine together with an inactivated vaccine compared with children receiving MMR alone 76–78. In a rare study of mortality following vaccination in a high-income country, Danish researchers reported reduced mortality for more doses of the DTaP vaccine received compared with fewer 79…”