Childhood neglect and adulthood involvement in HIV-related risk behaviors

Klein, Hugh; Elifson, Kirk W.; Sterk, Claire E.

doi:10.1016/j.chiabu.2006.08.005

Cited by 48 publications

(41 citation statements)

References 54 publications

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“…Childhood neglect has been linked to depression [34,35] , substance abuse disorder [36][37][38] , borderline personality disorder [39,40] , obsessive-compulsive disorder [41] , eating disorder [42,43] , and to anxiety in obsessive-compulsive disorder [44] and depression [45] . Hence, neglect probably contributes to psychiatric illness, and this may be mediated by negative effects on self-esteem [46] , affect regulation [45] and current significant relationships [47] . That aside, Brunner et al [18] proposed CEN to be a pathogenic risk factor for dissociation in adolescent psychiatric patients.…”

Section: Discussionmentioning

confidence: 99%

Association of Childhood Neglect with Adult Dissociation in Schizophrenic Inpatients

et al. 2009

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Background: Dissociation is often related to previous trauma and also occurs frequently in schizophrenia. Dissociation and psychosis may reflect a posttraumatic syndrome in some patients with schizophrenia. Sampling and Methods: In total, 80 patients diagnosed with schizophrenia were investigated by means of the Childhood Trauma Questionnaire (CTQ), the Dissociative Experience Scale and the Symptom Check List 90-R. CTQ subscales and groups reporting high and low dissociation were compared using MANOVA. Results: Childhood traumatic experiences were frequent [mean CTQ total score = 45.4 ± 17.5 (SD)]. Physical neglect was clearly associated with high dissociation, whereas abuse was not. Furthermore, there was a significant association of physical neglect with psychopathological distress not fully accounted for by dissociation. Conclusions: Dissociation may be specifically linked to childhood physical neglect in patients diagnosed with schizophrenia. Dissociation alone may not explain the effects of childhood maltreatment on adult psychopathology in schizophrenia; however, conclusions from the present study are limited due to its cross-sectional design.

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Section: Discussionmentioning

confidence: 99%

Association of Childhood Neglect with Adult Dissociation in Schizophrenic Inpatients

et al. 2009

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“…A history of childhood emotional invalidation and neglect seems to be linked with chronic emotional inhibition and low self-esteem in adulthood, with consequences related to depression, anxiety, and risky behaviors [Krause et al, 2003;Klein et al, 2007].…”

Section: Introductionmentioning

confidence: 99%

Relevance of perceived childhood neglect, 5‐HTT gene variants and hypothalamus–pituitary–adrenal axis dysregulation to substance abuse susceptibility

Gerra

Zaimovic²,

Castaldini³

et al. 2009

American J of Med Genetics Pt B

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The hypotheses of (1) gene x environment interaction in the susceptibility to experiment with drugs and (2) hypothalamus-pituitary-adrenal (HPA) axis involvement in mediating the effects of early adverse experiences and gene variants affecting serotonin function on substance abuse vulnerability were tested by investigating in 187 healthy adolescents the possible relevance of 5-HTT "S" polymorphism, childhood parental neglect reported retrospectively and HPA axis function to the susceptibility to experiment with illicit drugs. Higher frequency of the 5-HTT SS genotype seems to be associated with an increased susceptibility to use illegal psychotropic drugs among the adolescents. At the same time, reduced maternal care perception was found to represent a key intermediate factor of the association between SS polymorphism and drug use, suggesting that genetic factors and parental behavior concur to drug use susceptibility. Our results also confirm the relationship between basal plasma levels of cortisol and adrenocorticotropic hormone (ACTH) on the one hand, and retrospective measures of neglect during childhood: the higher the mother and father neglect CECA-Q scores, the higher the plasma levels of the two HPA hormones. Such positive relationship has been proved to be particularly effective and important when associated to the S-allele, both in homozygote and heterozygote individuals. However, when tested together with genotype and parental neglect, the effect of HPA hormones such as cortisol and ACTH was not found to improve significantly the explanatory power of the risk model.

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“…However, the current study considered prevalence of all cancers overall, in childhood and adulthood, in a cross-sectional study with a population-based sample while Brown et al (2010) looked at incident lung cancer using a prospective study design [15]. Evidence suggests that ACEs have been associated with risky sexual behaviors, [17][18][19] sexually transmitted infections, [7,8,19] chronic diseases such as cancer, [15,16] obesity, [42] depression [7,8,12,13], and smoking [42,43]. Research has also shown that ACEs are associated with risk factors for chronic disease [15] such as chronic obstructive pulmonary disease [44], liver disease [4], and ischemic heart disease [14].…”

Section: Discussionmentioning

confidence: 99%

“…ACEs have been linked to substance abuse [7][8][9][10][11], depression [7,8,12,13], cardiovascular disease [7,14], diabetes [7], cancer [7,15,16], risky sexual behaviors [17][18][19], sexually transmitted infections [7,8,19] suicidality [7,8,13,17,18], and premature mortality in adulthood [17]. Researchers have suggested examining multiple ACEs allowing for a potential assessment of a graded relationship between these exposures and health outcomes [6].…”

Section: Introductionmentioning

confidence: 99%

Childhood Maltreatment Is Associated with Larger Left Thalamic Gray Matter Volume in Adolescents with Generalized Anxiety Disorder

Prock¹

2015

Holistic Perspectives on Trauma

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Objective: Adverse childhood experiences (ACEs) are linked to multiple adverse health outcomes. This study examined the association between ACEs and cancer diagnosis.Methods: Data from the 2010 Behavioral Risk Factor Surveillance System (BRFSS) survey were used. The BRFSS is the largest ongoing telephone health survey, conducted in all US states, the District of Columbia, Puerto Rico, Guam and the U.S. Virgin Islands, and provides data on a variety of health issues among the non-institutionalized adult population. Principal component analysis (PCA) was used to derive components for ACEs. Multivariable logistic regression models were used to provide adjusted odds ratios (OR) and 95% confidence intervals (CI) for the association between ACE components and overall, childhood and adulthood cancer, adjusting for confounders such as age, gender, race/ethnicity, income, educational status, marital status, and insurance status.

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Childhood neglect and adulthood involvement in HIV-related risk behaviors

Cited by 48 publications

References 54 publications

Association of Childhood Neglect with Adult Dissociation in Schizophrenic Inpatients

Association of Childhood Neglect with Adult Dissociation in Schizophrenic Inpatients

Relevance of perceived childhood neglect, 5‐HTT gene variants and hypothalamus–pituitary–adrenal axis dysregulation to substance abuse susceptibility

Childhood Maltreatment Is Associated with Larger Left Thalamic Gray Matter Volume in Adolescents with Generalized Anxiety Disorder

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