Childhood Enuresis: Current Diagnostic Formulations, Salient Findings, and Effective Treatment Modalities

Thurber, Steven

doi:10.1016/j.apnu.2016.11.005

Cited by 19 publications

(21 citation statements)

References 25 publications

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“…The study also showed variable response of the included MNE children to previous vasopressin treatment, part had partial response, another was totally non-responsive, and a third group was temporarily responsive which points to the different etiological factors of the disease and the problem is not only disturbed nocturnal vasopressin secretion. This finding is in accordance with Thurber's work (Thurber 2017) who stated that MNE is a multifactorial disorder in which disturbed nocturnal vasopressin secretion constitutes a part but not the whole picture of etiology. The present study showed a high percent of inverted VP circadian rhythm (52.5%) and significant decrease in nocturnal/diurnal VP difference in enuretic children than controls pointing to the presence of nocturnal polyuria among enuretic children.…”

Section: Discussionsupporting

confidence: 92%

“…The study showed that MNE is more common in male children with positive family history of NE pointing to the possible hereditary factor in its pathogenesis. These results are in accordance with Thurber's work (Thurber 2017) who stated the importance of genetic role in pathogenesis of MNE and documented the presence of more than one affected member within the patient's family tree. The present study showed non-significant difference in the incidence of SBO in MNE children and healthy control subjects but enuretic children with SBO had history of poor response to desmopressin.…”

Section: Discussionsupporting

confidence: 92%

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Primary monosymptomatic nocturnal enuresis: an etiological study

Bahnasy

El-Heneedy

El-Seidy

et al. 2018

Egypt J Neurol Psychiatry Neurosurg

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Background: Nocturnal enuresis (NE) is a very common chronic pediatric problem with bad psychological consequences. Methods: Forty primary monosymptomatic nocturnal enuresis (MNE) children and 20 healthy controls were recruited in the study and subjected to history taking, neurological and urological examinations, and psychological assessment using the Arabic-translated and validated version of child behavior checklist, sleep architecture studying through onenight polysomnography (PSG), and vasopressin levels determination both diurnal and nocturnal. Results: Enuretic children had positive family history of NE in 42.5%, inverted vasopressin circadian rhythm in 52.5% and PSG changes in the form of increased N3 deep sleep % of total sleep time (TST), sleep stage transition index (SSTI), periodic limb movement index (PLMI), and snore index. Enuretic children PSG showed decreased deep sleep latency, N1% of TST, N2% of TST, and REM % of TST. The child behavior checklist showed higher anxious depressed symptoms, social problem, attention problems, and internalizing problems in enuretic children than control subjects. Conclusions: MNE is a heterogeneous disorder with multiple factors interplay in its pathogenesis. So, the management must be tailored patient by patient according to the dominating etiology.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 92%

Primary monosymptomatic nocturnal enuresis: an etiological study

Bahnasy

El-Heneedy

El-Seidy

et al. 2018

Egypt J Neurol Psychiatry Neurosurg

View full text Add to dashboard Cite

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“…In the United States, enuresis and encopresis diagnoses are more common among children. Recent estimates suggest that at least 5 to 7 million American children are diagnosed with nocturnal enuresis each year (Thurber, 2017). In addition, the rate of encopresis was found to be 1.5% for children between 7 and 8 years old and approximately 1% of 10- to 12-year-olds (Kod Dece & Saznanja, 2016).…”

Section: Theoretical and Research Basis For Treatmentmentioning

confidence: 99%

“…Urinary and fecal incontinence can create disturbances in a child’s school, family, and social environment (Thurber, 2017) and may have a negative impact on the afflicted child as well as other family members. Children with elimination disorders experience more symptoms of anxiety and depression compared with children without incontinence struggles, and those with fecal incontinence experience the highest rates of anxious/depressed symptoms (Equit, Klein, Braun-Bither, Graber, & von Gontard, 2014).…”

Section: Theoretical and Research Basis For Treatmentmentioning

confidence: 99%

Doctor, Snitch, and Weasel: Narrative Family Therapy With a Child Suffering From Encopresis and Enuresis

Fife

Hawkins

2019

Clinical Case Studies

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Children who experience enuresis and encopresis can face many difficulties, including social isolation, shame, embarrassment, anxiety, and depression. Due to the prevalence of enuresis and encopresis, it is essential for mental health professionals to understand the common symptoms and available treatment options for enuresis and encopresis, particularly to assist parents struggling to help their children overcome these challenges. Despite this need, there is very little clinical literature that incorporates a systemic approach for families who have a child diagnosed with enuresis and encopresis. Furthermore, common treatment approaches may unwittingly reinforce children’s perception that these problems are rooted in their identity. In an effort to address these concerns, the present case study aims to illustrate how a narrative therapy approach was utilized to effectively treat a child with enuresis and encopresis. Narrative therapy can uniquely assist children and their parents by helping them externalize the problem, overcome the problem-saturated view of their lives, and create new experiences where the problem is nonexistent.

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“…Parents have reported more often (71%) that NE had little or no impact on their child’s overall quality of life, as they believed it was a developmental condition [9]. This is supported by the fact that only half the amount of parents consult a medical practitioner for this condition [16], which suggests that the prevalence could be higher in the community than indicated by current documented Figures [17].…”

Section: Introductionmentioning

confidence: 99%

A randomised, double-blind, placebo-controlled clinical trial assessing the efficacy of bedtime buddy® for the treatment of nocturnal enuresis in children

et al. 2019

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BackgroundNocturnal enuresis (NE), or ‘bedwetting’, is a form of night-time urinary incontinence occurring in younger children. A diagnosis of NE can be socially disruptive and psychologically stressful for a child. The most common strategies used by parents to manage NE are waking the child during the night to use the bathroom and limiting the child’s water intake before going to bed. Behavioural or educational therapies for NE such as urotherapy or bladder retraining are widely accepted and considered as a mainstream treatment option for non-neurogenic lower urinary tract dysfunction in children. Pharmacotherapy also plays an ancillary role. However, there is no gold standard therapy or intervention to effectively manage NE.MethodsThis study aims to determine the efficacy of a herbal combination in the treatment of NE in children. The target population for this study is 80 children aged between 6 and 14 years old (males and females) who have primary nocturnal enuresis ≥3 per week (wet nights). The active group will receive one or two capsules per day containing 420 mg of a proprietary blend of Urox® (Seipel Group, Brisbane, Australia) containing Cratevox™ (Crataeva nurvala L; Capparidaceae; Varuna) stem bark extract standardised for 1.5% lupeol: non-standardised Equisetum arvense L. (Equisetaceae; Horsetail) stem extract; and, non-standardised Lindera aggregata Sims. The primary outcome for this study is the frequency of nocturia. Secondary outcomes include safety, quality of life, and daytime incontinence. Each participation will be involved in the trial for 32 weeks including contact with the research team every 2 weeks for the first 8 weeks and then every 8 weeks until trial completion.DiscussionThis study examines a novel treatment for an under-researched health condition affecting many children. Despite the availability of several therapies for NE, there is insufficient evidence to support the use of any one intervention and as such this randomised placebo-controlled phase II trial will be an important contribution to understanding potential new treatments for this condition.Trial registrationAustralian and New Zealand Clinical Trials Registration Number: 12618000288224.Protocol: 23 February 2018, version 1.1.

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Childhood Enuresis: Current Diagnostic Formulations, Salient Findings, and Effective Treatment Modalities

Cited by 19 publications

References 25 publications

Primary monosymptomatic nocturnal enuresis: an etiological study

Primary monosymptomatic nocturnal enuresis: an etiological study

Doctor, Snitch, and Weasel: Narrative Family Therapy With a Child Suffering From Encopresis and Enuresis

A randomised, double-blind, placebo-controlled clinical trial assessing the efficacy of bedtime buddy® for the treatment of nocturnal enuresis in children

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