Childhood cancers in India: Burden, barriers, and breakthroughs

Arora, Brijesh; Kanwar, Vikramjit S.

doi:10.4103/0019-509x.55543

Cited by 22 publications

(12 citation statements)

References 11 publications

(16 reference statements)

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“…Such a delay in presentation, along with unfavorable biology leads to a need for more intense treatment, resulting in higher treatment-related morbidity and mortality. [18] Treatment refusal or abandonment, besides treatment-related death, is a frequent unwanted outcome. Reasons for treatment abandonment in India include financial problems, transportation difficulties, beliefs about cancer curability, fear and experience of severe side effects, child refusal (in adolescents), girl child, and dissatisfaction with the treating hospital.…”

Section: Discussionmentioning

confidence: 99%

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Clinical profile of pediatric oncology patients treated by external beam radiotherapy: An institutional experience

Suhag

Vats

et al. 2017

Indian J Med Paediatr Oncol

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Introduction:Pediatric tumors are a heterogeneous group of malignant conditions requiring multimodal treatment, and management of such cases is at time challenging. We present the clinical profile of pediatric cancer patients who received radiation, either alone or as adjuvant to surgery and chemotherapy; in prophylactic, radical or palliative clinical setting.Aim:This study was envisaged to review our experience of pediatric oncology cases, their clinical and morphological profile, dosage schedule of radiotherapy, and the therapy induced complications.Settings and Design:This was a retrospective, observational study carried out in an apex tertiary care cancer institute of government set-up in a developing country.Materials and Methods:The treatment charts and clinical summary of patients who had received radiation over the last 5 years period were retrieved and perused. Various clinical and pathological parameters were studied and inferences drawn.Results:A total of 50 patients got radiation over 5 year study-period, including 37 male and 13 female patients. The commonest age group of presentation was 8-12 years followed by 13-16 years. The mean age of presentation was 9.3 years. The most common diagnosis was hematological malignancies followed by CNS tumors with 21 and 13 patients respectively. Overall the most common indication of RT was in adjuvant setting after surgery as the definitive management, where 24 patients were irradiated; and the next common indication was prophylactic cranial irradiation in 14 patients of childhood leukemias. 10 patients tolerated treatment with Grade 1 site-specific or systemic toxicities while 7 patients developed Grade 2 and more systemic toxicities. 9 patients received craniospinal irradiation, common indications being medulloblastoma and Atypical teratoma rhabdoid tumor (ATRT). 3 patients received concurrent chemotherapy with weekly Inj Vincristine. 17 patients required sedation or short general anaesthesia for radiation planning and execution.Conclusion:External beam Radiotherapy constitutes an important component of management of pediatric cancers. One should be judicious in Radiotherapy planning, execution and monitoring acute and delayed toxicities.

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Section: Discussionmentioning

confidence: 99%

“…[12] In the developed countries, 80% of the children with cancer are cured, but the scenario in India continues to be dismal where cure rates are estimated to be between 10% and 30%. [34] Pediatric oncology is an upcoming specialty in India and lots of gaps need to be filled in this arena.…”

Section: Introductionmentioning

confidence: 99%

Clinical profile of pediatric oncology patients treated by external beam radiotherapy: An institutional experience

Suhag

Vats

et al. 2017

Indian J Med Paediatr Oncol

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“…The outcome of hematological cancers in terms of long-term survival has greatly improved from 20% to 60% in acute lymphoblastic leukemia (ALL), from <70% to more than 90% in Hodgkin’s disease, from 30% to 70% in non-Hodgkin’s lymphoma (NHL) and from 10% to 40% in acute myeloblastic leukemia (AML). [7–13] Similarly, the outcome in solid tumors has also improved. However, the outcome is still considerably poor compared to western figures, especially in tumors like retinoblastoma, leukemias, CNS tumors and germ cell tumors.…”

Section: Pediatric Oncology Servicementioning

confidence: 99%

“…Furthermore, there is considerable disparity in outcomes between centers with only a few achieving outcome comparable to the west. [611–13]…”

Section: Pediatric Oncology Servicementioning

confidence: 99%

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Pediatric oncology in India: Past, present and future

Arora

Banavali

2009

Indian J Med Paediatr Oncol

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The role of twinning in sustainable care for children with cancer: A TIPPing point? SIOP PODC Working Group on Twinning, Collaboration, and Support

Kanwar

Schwartz

Salifu

et al. 2020

Pediatric Blood & Cancer

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With the World Health Organization (WHO) Global Initiative for Childhood Cancer, there is renewed interest in sustainable interventions to improve childhood cancer care in low-/middle-income countries (LMICs). Practitioners in LMICs have traditionally practiced "twinning," i.e., targeted international pediatric oncology partnerships (TIPPs) between one or more institutions in a high-income country (HIC) and an LMIC, to improve care for children with cancer in the latter. The International Society of Paediatric Oncology Committee for Paediatric Oncology in Developing Countries Working Group on Twinning, Collaboration, and Support reviewed guidelines from https: //cancerpointe.com and the current literature, gathered input from practitioners in LMICs, and in this article discuss the role of TIPPs in the WHO initiative.

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Childhood cancers in India: Burden, barriers, and breakthroughs

Cited by 22 publications

References 11 publications

Clinical profile of pediatric oncology patients treated by external beam radiotherapy: An institutional experience

Clinical profile of pediatric oncology patients treated by external beam radiotherapy: An institutional experience

Pediatric oncology in India: Past, present and future

The role of twinning in sustainable care for children with cancer: A TIPPing point? SIOP PODC Working Group on Twinning, Collaboration, and Support

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