Childhood bullous dermatitis herpetiformis. Negative immunofluorescent tests

Jordon, R. E.

doi:10.1001/archderm.101.6.629

Cited by 26 publications

(3 citation statements)

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“…In our earlier work we treated this group as a mixed form DH-BP in children )1 tJie exact counterpart of such mixed forms in adults (Jablonska et ah, 1976;Chorzelski & Jablonska, 1976;Dabrowski et al, 1977). The distinctness of this form has been emphasized by some authors (McGuire & Nordlund, 1973;Prystowsky & Gilliam, 1976;Esterly et al, 1977;Clayton & Feiwel, 1977), who adapted the name of CBDC, originally coined for the forms with no immunological phenomena detectable in the skin (Jordon et al, 1970;Bean et al, 1971).…”

Section: Discussionmentioning

confidence: 99%

IgA linear dermatosis of childhood (chronic bullous disease of childhood)

Chorzelski¹,

Jabłońska²

1979

Br J Dermatol

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SUMMARY Of twenty‐seven cases of subepidermal blistering disease of children twelve corresponded clinically, histologically and immunologically to dermatitis herpetiforms of adults, six to bullous pemphigoid, and eight to chronic Bullous disease of childhood (CBDC), i.e. IgA linear dermatosis. This latter disease seems to be a distinct entity, different from both dermatitis herpetiformis and Bullous pemphigoid, and is characterized immunopathologically by linear IgA deposits at the basement membrane zone. These cases usually do not show intestinal involvement and respond well to combined treatment with sulphones and corticosteroids, whereas sulphones or sulphapyridine alone are, even in very high doses, not sufficient for full control of the disease. CBDC or IgA linear dermatosis of childhood may be regarded as a counterpart of IgA linear dermatosis of adults.

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Section: Discussionmentioning

confidence: 99%

IgA linear dermatosis of childhood (chronic bullous disease of childhood)

Chorzelski¹,

Jabłońska²

1979

Br J Dermatol

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“…Jordan and Bean in 1970 described six children with a subepidermai biistering disease with negative findings for IgG on direct and indirect immunofluorescence. They called this disorder chronic bullous disease of childhood (6). In 1976 Prystowsky and Giiliam were the first to demonstrate linear IgA and C3 deposition along the basement membrane (7).…”

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confidence: 99%

Linear IgA Bullous Dermatosis in a Neonate

Hruza

Mallory

Fitzgibbons

et al. 1993

Pediatric Dermatology

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A newborn black boy had two facial blisters at birth that progressed to bullous lesions over the trunk, genitals, extremities, and oral and tracheal mucosa. A biopsy specimen demonstrated a subepidermal bulla with mixed eosinophilic and neutrophilic, inflammatory infiltrate. Direct immunofluorescence showed linear IgA, IgG, and C3 depositions along the basement membrane zone, consistent with a diagnosis of childhood linear IgA bullous dermatosis (chronic bullous dermatosis of childhood). The skin disease was controlled with combined prednisone and dapsone. This is the youngest reported patient with the disease. Linear IgA bullous dermatosis should be considered in the differential diagnosis of blistering diseases of the newborn, and immunofluorescence should be performed on a skin biopsy specimen.

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“…[ 6 7 ] It is considered to be the childhood variant of adult-onset disease Linear IgA disease because of overlapping immunogenetics and immunopathology. [ 8 ]…”

Section: Discussionmentioning

confidence: 99%

Successful Treatment of Refractory Chronic Bullous Disease of Childhood with Rituximab

Mitra

Bhatnagar

Singh

et al. 2022

Indian Dermatology Online Journal

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Chronic bullous disease of childhood is a rare subepidermal bullous disease with a hallmark of linear IgA deposition along basement membrane zone seen on direct immunofluorescence. We report a case of a 2-year-old male child, who had recurrent and multiple bullous eruptions over body and he was not responding to conventional therapy. He had earlier developed a drug reaction to dapsone which is considered the drug of choice for this condition. We report successful management of this case with injection rituximab which is a chimeric monoclonal antibody against CD20, which is primarily found on the surface of B cells.

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Childhood bullous dermatitis herpetiformis. Negative immunofluorescent tests

Cited by 26 publications

References 0 publications

IgA linear dermatosis of childhood (chronic bullous disease of childhood)

IgA linear dermatosis of childhood (chronic bullous disease of childhood)

Linear IgA Bullous Dermatosis in a Neonate

Successful Treatment of Refractory Chronic Bullous Disease of Childhood with Rituximab

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