Chick Sox10, a transcription factor expressed in both early neural crest cells and central nervous system

Cheng, Yi-Chuan; Cheung, Martin; Abu‐Elmagd, Muhammad; Orme, Alex; Scotting, Paul J.

doi:10.1016/s0165-3806(00)00049-3

Cited by 163 publications

(141 citation statements)

References 32 publications

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“…[37][38][39][40][41][42][43][44][45][46][47][48] The principal differentially expressed genes upregulated in neurothekeomas and cellular fibrous histiocytomas over nerve sheath myxomas and schwannomas consisted of those encoding various metalloproteinases and glycoproteins. These genes are involved in extracellular matrix growth and remodeling, and cell adhesion in fibroblasts and macrophages (Table 6).…”

Section: Resultsmentioning

confidence: 99%

Differential gene expression profiles of neurothekeomas and nerve sheath myxomas by microarray analysis

Sheth

Binder

et al. 2011

Modern Pathology

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Section: Resultsmentioning

confidence: 99%

Differential gene expression profiles of neurothekeomas and nerve sheath myxomas by microarray analysis

Sheth

Binder

et al. 2011

Modern Pathology

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“…The SMP + sorted cells from E10.5 quail nerves also express the myelin protein P0 characteristic of Schwann cells (Bhattacharyya et al, 1991). In addition, they express the transcription factor Sox10 (Cheng et al, 2000) and the HNK1 epitope (Tucker et al, 1984). These markers are present in vivo in early NCCs and later in PNS cells, including Schwann cells, but are lost by mesenchymal and melanocytic NC derivatives.…”

Section: Characterisation Of the Transition From Schwann Cells To Myomentioning

confidence: 99%

“…In order to further characterise the Schwann cell-myofibroblast phenotype transition, we have verified the expression, by differentiating αSMA + cells, of additional markers, expressed by both NCCs and differentiated Schwann cells, that is, the transcription factor gene Sox10 (Cheng et al, 2000) and the HNK1 surface carbohydrate epitope (Abo andBalch, 1981, Tucker et al, 1984). Moreover, we examined Slug expression in the cultures.…”

Section: Marker Expression In the Transition Of Schwann Cells To Myofmentioning

confidence: 99%

The instability of the neural crest phenotypes: Schwann cells can differentiate into myofibroblasts

Real

Glavieux-Pardanaud²,

Vaigot³

et al. 2005

Int. J. Dev. Biol.

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“…Sox10 expression has been reported in the cranial nerves, ventricular zone of the brain, spinal cord, and pineal gland (Cheng et al, 2000). However, brain tissue does not penetrate well for ␤Gal staining, and future analysis of frozen sections will be required to confirm the presence of Sox10␤GeoBAC expression in these structures.…”

Section: However the Sox10mentioning

confidence: 99%

Distant regulatory elements in a Sox10‐βGEO BAC transgene are required for expression of Sox10 in the enteric nervous system and other neural crest‐derived tissues

Deal

Cantrell

Chandler

et al. 2006

Developmental Dynamics

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Sox10 is an essential transcription factor required for development of neural crest-derived melanocytes, peripheral glia, and enteric ganglia. Multiple transcriptional targets regulated by Sox10 have been identified; however, little is known regarding regulation of Sox10. High sequence conservation surrounding 5 exons 1 through 3 suggests these regions might contain functional regulatory elements. However, we observed that these Sox10 genomic sequences do not confer appropriate cell-specific transcription in vitro when linked to a heterologous reporter. To identify elements required for expression of Sox10 in vivo, we modified bacterial artificial chromosomes (BACs) to generate a Sox10␤GeoBAC transgene. Our approach leaves endogenous Sox10 loci unaltered, circumventing haploinsufficiency issues that arise from gene targeting. Sox10␤GeoBAC expression closely approximates Sox10 expression in vivo, resulting in expression in anterior dorsal neural tube at embryonic day (E) 8.5 and in cranial ganglia, otic vesicle, and developing dorsal root ganglia at E10.5. Characterization of Sox10␤GeoBAC expression confirms the presence of essential regulatory regions and additionally identifies previously unreported expression in thyroid parafollicular cells, thymus, salivary, adrenal, and lacrimal glands. Fortuitous deletions in independent Sox10␤GeoBAC lines result in loss of transgene expression in peripheral nervous system lineages and coincide with evolutionarily conserved regions. Our analysis indicates that Sox10 expression requires the presence of distant cis-acting regulatory elements. The Sox10␤GeoBAC transgene offers one avenue for specifically testing the role of individual conserved regions in regulation of Sox10 and makes possible analysis of Sox10؉ derivatives in the context of normal neural crest development.

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Chick Sox10, a transcription factor expressed in both early neural crest cells and central nervous system

Cited by 163 publications

References 32 publications

Differential gene expression profiles of neurothekeomas and nerve sheath myxomas by microarray analysis

Differential gene expression profiles of neurothekeomas and nerve sheath myxomas by microarray analysis

The instability of the neural crest phenotypes: Schwann cells can differentiate into myofibroblasts

Distant regulatory elements in a Sox10‐βGEO BAC transgene are required for expression of Sox10 in the enteric nervous system and other neural crest‐derived tissues

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