Chemotherapy-induced transverse white lines in the fingernails

ARITRACTIn 4M NaCl solutions (dC-dG) NMR spectroscopy gives evidence for sequence-dependent conformations or right handed deoxynucleotides (1-9). Assignments have recently been made for phosphodiester groups in the sugar-phosphate backbones ot snort oligonucleotides using 31P-lH decoupling experiments (10-12), two dimensional NMR 31P-lH correlation spectroscopy (13), and from 170 labeled experiments (14). Also, 31P NMR spectra of the left handed Z DNA of polynucleotides show two characteristic signals with separation or ca. 0.5-1.5 ppm, which can be used to detect the presence of Z DNA in solution (3,6,8,9,(15)(16)(17)(18)(19)(20)(21)(22)(23). It is usual to assume that the downfield and upfield components correspond to predominantly gt and gg conformations, respectively, of the i and a torsion angles (24) in the 03'-P-05' linkages (6,(15)(16)(17)(18)(19)(20)(21)(22)(23)

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“…25 and 26 and references cited therein). So far, no relaxation studies of internal and overail motions in Z DNA have been reported.…”

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confidence: 99%

³¹P-NMR analysis of the B to Z transition in double-stranded (dC-dG)₃, and (dC-dG)₄in high salt solution

Holak¹,

Borer²,

Levy³

et al. 1984

Nucl Acids Res

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“…Transverse striate leukonychia is a manifestation of nail matrix injury, resulting in a disturbance of nail plate keratinization. This may be caused by chemotherapy using multiple-drug regimens (17,18). The leukonychia is believed to result from the formation of air pockets or the retention of nuclei within the nail plate (19)(20)(21).…”

Section: Discussionmentioning

confidence: 99%

Transverse Striate Leukonychia Associated with Cancer Chemotherapy

Boxall

1991

Pediatric Dermatology

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Drug Reactions

Breathnach

BChir²,

Dermatologist³

2010

Rook's Textbook of Dermatology

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Chemotherapy-induced transverse white lines in the fingernails

Cited by 8 publications

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³¹P-NMR analysis of the B to Z transition in double-stranded (dC-dG)₃, and (dC-dG)₄in high salt solution

³¹P-NMR analysis of the B to Z transition in double-stranded (dC-dG)₃, and (dC-dG)₄in high salt solution

Transverse Striate Leukonychia Associated with Cancer Chemotherapy

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Chemotherapy-induced transverse white lines in the fingernails

Cited by 8 publications

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31P-NMR analysis of the B to Z transition in double-stranded (dC-dG)3, and (dC-dG)4in high salt solution

31P-NMR analysis of the B to Z transition in double-stranded (dC-dG)3, and (dC-dG)4in high salt solution

Transverse Striate Leukonychia Associated with Cancer Chemotherapy

Drug Reactions

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Product

Resources

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³¹P-NMR analysis of the B to Z transition in double-stranded (dC-dG)₃, and (dC-dG)₄in high salt solution

³¹P-NMR analysis of the B to Z transition in double-stranded (dC-dG)₃, and (dC-dG)₄in high salt solution