Chemotherapy for metastatic soft tissue sarcomas – another full circle?

The Treatment and Outcome of Patients With Soft Tissue Sarcomas and Synchronous Metastases

“…Response rates have ranged from 15 to 48%, but there has been little impact on overall survival. 2,18,19 Approximately one-third of the patients was treated with three or more different chemotherapy regimens with no apparent impact on survival. It is conceivable the various chemotherapeutic regimens or radiation therapy had an impact on survival.…”

The Treatment and Outcome of Patients With Soft Tissue Sarcomas and Synchronous Metastases

“…Response rates have ranged from 15 to 48%, but there has been little impact on overall survival. 2,18,19 Approximately one-third of the patients was treated with three or more different chemotherapy regimens with no apparent impact on survival. It is conceivable the various chemotherapeutic regimens or radiation therapy had an impact on survival.…”

Chemotherapy for adult soft tissue sarcoma

“…However, subsequent studies were unable to reproduce these results [14], and interest turned towards combinations containing doxorubicin and ifosfamide. Of these, the EORTC doxorubicin/ifosfamide regimen, the Dana Farber "MAID" combination (doxorubicin, ifosfamide and OTIC), and the Scandinavian Sarcoma Group "VIG" regimen (etoposide and ifosfamide) all produced overall response rates of 35-45%, with complete responses in the 10% range [7,[15][16][17][18].…”

Metastasectomy following Chemotherapy in Patients with Advanced Soft Tissue Sarcomas

“…drugs doxorubicin, ifosfamide and DTIC alone or in combina tion lead to remission rates between 20 and 40% [1][2][3][4][5][6][7][8]19] with only a few complete remissions. Cure with presently available chemotherapy regimens remains a rare exception.…”

The Treatment and Outcome of Patients With Soft Tissue Sarcomas and Synchronous Metastases

“…Response rates have ranged from 15 to 48%, but there has been little impact on overall survival. 2,18,19 Approximately one-third of the patients was treated with three or more different chemotherapy regimens with no apparent impact on survival. It is conceivable the various chemotherapeutic regimens or radiation therapy had an impact on survival.…”

Chemotherapy for adult soft tissue sarcoma

“…However, subsequent studies were unable to reproduce these results [14], and interest turned towards combinations containing doxorubicin and ifosfamide. Of these, the EORTC doxorubicin/ifosfamide regimen, the Dana Farber "MAID" combination (doxorubicin, ifosfamide and OTIC), and the Scandinavian Sarcoma Group "VIG" regimen (etoposide and ifosfamide) all produced overall response rates of 35-45%, with complete responses in the 10% range [7,[15][16][17][18].…”

Metastasectomy following Chemotherapy in Patients with Advanced Soft Tissue Sarcomas

“…drugs doxorubicin, ifosfamide and DTIC alone or in combina tion lead to remission rates between 20 and 40% [1][2][3][4][5][6][7][8]19] with only a few complete remissions. Cure with presently available chemotherapy regimens remains a rare exception.…”

The Treatment and Outcome of Patients With Soft Tissue Sarcomas and Synchronous Metastases

“…Response rates have ranged from 15 to 48%, but there has been little impact on overall survival. 2,18,19 Approximately one-third of the patients was treated with three or more different chemotherapy regimens with no apparent impact on survival. It is conceivable the various chemotherapeutic regimens or radiation therapy had an impact on survival.…”

Chemotherapy for adult soft tissue sarcoma

“…However, subsequent studies were unable to reproduce these results [14], and interest turned towards combinations containing doxorubicin and ifosfamide. Of these, the EORTC doxorubicin/ifosfamide regimen, the Dana Farber "MAID" combination (doxorubicin, ifosfamide and OTIC), and the Scandinavian Sarcoma Group "VIG" regimen (etoposide and ifosfamide) all produced overall response rates of 35-45%, with complete responses in the 10% range [7,[15][16][17][18].…”

Metastasectomy following Chemotherapy in Patients with Advanced Soft Tissue Sarcomas

“…drugs doxorubicin, ifosfamide and DTIC alone or in combina tion lead to remission rates between 20 and 40% [1][2][3][4][5][6][7][8]19] with only a few complete remissions. Cure with presently available chemotherapy regimens remains a rare exception.…”