Chemotactic synthetic vesicles: Design and applications in blood-brain barrier crossing

Joseph, Adrian; Contini, Claudia; Cecchin, Denis; Nyberg, Sophie; Ruiz‐Pérez, Lorena; Gaitzsch, Jens; Fullstone, Gavin; Tian, Xiaohe; Azizi, Juzaili; Preston, Jane E.; Volpe, Giorgio; Battaglia, Giuseppe

doi:10.1126/sciadv.1700362

Cited by 223 publications

(211 citation statements)

References 56 publications

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“…To form polymersomes with two separate domains of different permeability, two different copolymers were mixed with a molar ratio that controlled the topology of the polymersome membrane. [43] Poly[oligo(ethylene glycol) methyl methacrylate]- block -poly[2-(diisopropylamino)ethyl methacrylate] (POEGMA- b -PDPA) was mixed with poly(ethylene oxide)- block -poly(butylene oxide) (PEO- b -PBO) at an optimal 9:1 molar ratio. This resulted in a spherical POEGMA- b -PDPA polymersome of 100 nm in diameter and membrane thickness of 6.4 nm with a small and more permeable PEO- b -PBO bud of 30 nm in diameter and membrane thickness of 2.4 nm.…”

Section: Controlling Physicochemical Properties Of Polymersome Membranementioning

confidence: 99%

Engineering Polymersomes for Diagnostics and Therapy

Leong

Teo

Aakalu

et al. 2018

Adv Healthcare Materials

103

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Engineered polymer vesicles, termed as polymersomes, confer a flexibility to control their structure, properties, and functionality. Self-assembly of amphiphilic copolymers leads to vesicles consisting of a hydrophobic bilayer membrane and hydrophilic core, each of which is loaded with a wide array of small and large molecules of interests. As such, polymersomes are increasingly being studied as carriers of imaging probes and therapeutic drugs. Effective delivery of polymersomes necessitates careful design of polymersomes. Therefore, this review article discusses the design strategies of polymersomes developed for enhanced transport and efficacy of imaging probes and therapeutic drugs. In particular, the article focuses on overviewing technologies to regulate the size, structure, shape, surface activity, and stimuli- responsiveness of polymersomes and discussing the extent to which these properties and structure of polymersomes influence the efficacy of cargo molecules. Taken together with future considerations, this article will serve to improve the controllability of polymersome functions and accelerate the use of polymersomes in biomedical applications.

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Section: Controlling Physicochemical Properties Of Polymersome Membranementioning

confidence: 99%

Engineering Polymersomes for Diagnostics and Therapy

Leong

Teo

Aakalu

et al. 2018

Adv Healthcare Materials

103

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“…The use of advanced microscopy techniques makes possible to visualise the surface topology of the most effective nanoscale vector present in nature, the virus and suggests that the presence of a pattern or domain on the NP surface facilitates cellular endocytosis by matching specific targets of the cellular surface. This new understanding is opening new horizons in the development of nanotechnology making it possible to manipulate, control and mimic membrane properties in order to create fully synthetic, nature inspired systems [72,73].…”

Section: Nanoparticle-membrane Interactions: Elastic Theorymentioning

confidence: 99%

Nanoparticle–membrane interactions

Contini

Schneemilch

Gaisford

et al. 2017

Journal of Experimental Nanoscience

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143

104

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Engineered nanomaterials have a wide range of applications and as a result, are increasingly present in the environment. While they offer new technological opportunities, there is also the potential for adverse impact, in particular through possible toxicity. In this review, we discuss the current state of the art in the experimental characterisation of nanoparticle-membrane interactions relevant to the prediction of toxicity arising from disruption of biological systems. One key point of discussion is the urgent need for more quantitative studies of nano-bio interactions in experimental models of lipid system that mimic in vivo membranes.

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“…If the capping group at the end of the axle is removed, however, it becomes physically possible for the wheel to slide off the axle, and this structure is known as a pseudorotaxane. At the nanoscale, compartmentalised structures are also useful in mediating on-demand release of cargo, illustrated by smart nanocarriers based on DNA origami 78 (Section 3.2), and in acting as a barrier for sustaining a concentration gradient across the soft nanomotors 61,64 (Section 3.1).…”

Section: Discussion and Outlookmentioning

confidence: 99%

“…In addition, it was shown that the chemotactic vesicles were able to penetrate more effectively through the blood brain barrier than standard vesicles. 61 Self-assembly of poly(styrene)-poly(ethylene glycol) (PS-PEG) block copolymers was also used to form self-propelling vesicles (Fig. 7b).…”

mentioning

confidence: 99%