1977
DOI: 10.1001/archderm.113.3.285
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Chemosurgery for melanoma

Abstract: Microscopically controlled excision of melanoma by the chemosurgical method ensures complete eradication of any unsuspected outgrowths from the clinically observed tumor mass. The method differs from the chemosurgical techniques used for excision of cutaneous carcinomas in the following two respects: the tissues always are chemically fixed in situ before any incisions are made in order to minimize the chance of dissemination, and an extra margin of tissues is removed after reaching a microscopically melanoma-f… Show more

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Cited by 29 publications
(23 citation statements)
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“…Subsequent stages are undertaken pending the findings from the histologic evaluation. It has been noted to be effective in melanoma 45–50 and offers the distinct advantage over methods that use vertical sections or “bread loafing” of analyzing virtually 100% of the tumor borders 51 …”
Section: Mohs Micrographic Surgerymentioning
confidence: 99%
“…Subsequent stages are undertaken pending the findings from the histologic evaluation. It has been noted to be effective in melanoma 45–50 and offers the distinct advantage over methods that use vertical sections or “bread loafing” of analyzing virtually 100% of the tumor borders 51 …”
Section: Mohs Micrographic Surgerymentioning
confidence: 99%
“…Finally, the use of MMS to treat melanoma is supported by a substantial amount of evidence indicating that it provides cure rates equal to or exceeding those of WLE for MIS and MM. 1 – 5 , 7 , 8 , 10 , 12 28 …”
Section: Rationale For the Use Of Mms For MM And Mismentioning
confidence: 99%
“…1 Although the original 1941 publication of his technique reported primarily on basal and squamous cell carcinomas, 1 Mohs published a case series of twenty patients with cutaneous melanoma successfully treated with this chemosurgery less than a decade later. 2 , 3 Despite the early evidence of the effectiveness of chemosurgery in treating both keratinocyte carcinomas and melanoma, 1 , 2 , 4 , 5 the technique was not widely practiced until 1974 when a modified version (renamed MMS) using fresh tissue and frozen sections was first described. 6 , 7 These modifications significantly reduced the time involved with the procedure and eliminated the additional discomfort caused by the zinc chloride paste without sacrificing cure rates.…”
Section: Introductionmentioning
confidence: 99%
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“…Mohs berichtete erstmals im Jahre 1950 über 20 Melanome, und später im Jahre 1977 über 103 Fälle, die er mit seiner Methode behandelt hatte [2, 12]. Das rezidivfreie Überleben und das Gesamtüberleben dieser Patienten war besser als bei vergleichbaren Kollektiven, die konventionell behandelt worden waren.…”
Section: D‐histologie Beim Melanom (Vgl Tabelle 1)unclassified