Chemosensitivities of human clonogenic breast tumor cells

Effect of hormonal manipulation and doxorubicin administration on cell cycle kinetics of human breast cancer cells

“…Theoretically this growth stimulation can be used to recruit quiescent cells into the cell cycle, rendering them more vulnerable to the letal effects of concomitant cytotoxic drugs. In vitro studies indicated that the combination of growth stimulation and cytotoxic therapy can lead to an enhanced cell kill in breast cancer (Weichselbaum et al, 1978;Clarke et al, 1985;Hug et al, 1986;Bontenbal et al, 1988). Several clinical studies already make use of this concept of recruitment.…”

“…One of the explanations for this relative insensitivity can be kinetic resistance (Osborne, 1981). Growth stimulation of slowly growing breast tumour cells in vitro, followed by cell cycle active chemotherapy, results in an augmented cytoxic effect of the chemotherapeutic drug (Weichselbaum et al, 1978;Clarke et al, 1985;Hug et al, 1986;Bontenbal et al, 1988). This recruitment concept has been clinically applied with diverse results (Allegra, 1983;Lippman et al, 1984;Paridaens et al, 1987;Conte et al, 1987;Lipton et al, 1987).…”

Effect of hormonal manipulation and doxorubicin administration on cell cycle kinetics of human breast cancer cells

“…Theoretically this growth stimulation can be used to recruit quiescent cells into the cell cycle, rendering them more vulnerable to the letal effects of concomitant cytotoxic drugs. In vitro studies indicated that the combination of growth stimulation and cytotoxic therapy can lead to an enhanced cell kill in breast cancer (Weichselbaum et al, 1978;Clarke et al, 1985;Hug et al, 1986;Bontenbal et al, 1988). Several clinical studies already make use of this concept of recruitment.…”

“…One of the explanations for this relative insensitivity can be kinetic resistance (Osborne, 1981). Growth stimulation of slowly growing breast tumour cells in vitro, followed by cell cycle active chemotherapy, results in an augmented cytoxic effect of the chemotherapeutic drug (Weichselbaum et al, 1978;Clarke et al, 1985;Hug et al, 1986;Bontenbal et al, 1988). This recruitment concept has been clinically applied with diverse results (Allegra, 1983;Lippman et al, 1984;Paridaens et al, 1987;Conte et al, 1987;Lipton et al, 1987).…”

The response of human breast cancer cells to glucagon

“…Whilst the cytotoxic effects of ADR are increased in MCF-7 cells treated in medium containing lo-' M-E2, epidermal growth factor, insulin and hydrocortisone (Hug et al, 1986), E2 alone fails to potentiate the cytotoxic effects of ADR (Fig. la).…”

Effect of hormonal manipulation and doxorubicin administration on cell cycle kinetics of human breast cancer cells

“…Theoretically this growth stimulation can be used to recruit quiescent cells into the cell cycle, rendering them more vulnerable to the letal effects of concomitant cytotoxic drugs. In vitro studies indicated that the combination of growth stimulation and cytotoxic therapy can lead to an enhanced cell kill in breast cancer (Weichselbaum et al, 1978;Clarke et al, 1985;Hug et al, 1986;Bontenbal et al, 1988). Several clinical studies already make use of this concept of recruitment.…”

“…One of the explanations for this relative insensitivity can be kinetic resistance (Osborne, 1981). Growth stimulation of slowly growing breast tumour cells in vitro, followed by cell cycle active chemotherapy, results in an augmented cytoxic effect of the chemotherapeutic drug (Weichselbaum et al, 1978;Clarke et al, 1985;Hug et al, 1986;Bontenbal et al, 1988). This recruitment concept has been clinically applied with diverse results (Allegra, 1983;Lippman et al, 1984;Paridaens et al, 1987;Conte et al, 1987;Lipton et al, 1987).…”

The response of human breast cancer cells to glucagon

“…Whilst the cytotoxic effects of ADR are increased in MCF-7 cells treated in medium containing lo-' M-E2, epidermal growth factor, insulin and hydrocortisone (Hug et al, 1986), E2 alone fails to potentiate the cytotoxic effects of ADR (Fig. la).…”

Effect of hormonal manipulation and doxorubicin administration on cell cycle kinetics of human breast cancer cells

“…Theoretically this growth stimulation can be used to recruit quiescent cells into the cell cycle, rendering them more vulnerable to the letal effects of concomitant cytotoxic drugs. In vitro studies indicated that the combination of growth stimulation and cytotoxic therapy can lead to an enhanced cell kill in breast cancer (Weichselbaum et al, 1978;Clarke et al, 1985;Hug et al, 1986;Bontenbal et al, 1988). Several clinical studies already make use of this concept of recruitment.…”

“…One of the explanations for this relative insensitivity can be kinetic resistance (Osborne, 1981). Growth stimulation of slowly growing breast tumour cells in vitro, followed by cell cycle active chemotherapy, results in an augmented cytoxic effect of the chemotherapeutic drug (Weichselbaum et al, 1978;Clarke et al, 1985;Hug et al, 1986;Bontenbal et al, 1988). This recruitment concept has been clinically applied with diverse results (Allegra, 1983;Lippman et al, 1984;Paridaens et al, 1987;Conte et al, 1987;Lipton et al, 1987).…”

The response of human breast cancer cells to glucagon

“…Whilst the cytotoxic effects of ADR are increased in MCF-7 cells treated in medium containing lo-' M-E2, epidermal growth factor, insulin and hydrocortisone (Hug et al, 1986), E2 alone fails to potentiate the cytotoxic effects of ADR (Fig. la).…”