2002
DOI: 10.1007/bf02573893
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Abstract: Exclusive CRT approach is not safe to treat patients with low infiltrative rectal carcinoma.

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Cited by 71 publications
(35 citation statements)
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“…All reports indicate that distant metastases in cCR patients are rare, being at a maximum of 10% patients. Outcomes from other studies are presented in Table II [23][24][25][26][27]. In several of these, the decision not to treat metastases in regional lymph nodes (cN+) was not a contraindication for watch-and-wait [6,9,18].…”
Section: Long-term Results In Ccr Patients Undergoing Watch-and-waitmentioning
confidence: 99%
“…All reports indicate that distant metastases in cCR patients are rare, being at a maximum of 10% patients. Outcomes from other studies are presented in Table II [23][24][25][26][27]. In several of these, the decision not to treat metastases in regional lymph nodes (cN+) was not a contraindication for watch-and-wait [6,9,18].…”
Section: Long-term Results In Ccr Patients Undergoing Watch-and-waitmentioning
confidence: 99%
“…Many previous studies reported that LE after nCRT showed oncologic outcomes similar to that of radical surgery [8,9,10,11,12,13,14,15]; however, no definite conclusions have been derived to date because of the limitations of retrospective study designs. Moreover, the safety and feasibility of the wait-and-see approach is still controversial because of conflicting results from previous studies; some studies reported surprisingly excellent oncologic outcomes [16,17], while others reported disappointing results [18,19,20]. …”
Section: Introductionmentioning
confidence: 98%
“…Previous studies reported that the tumor regression grade is associated with patient survival [7] and that pathologic complete responders have better oncologic outcomes [4,5,6]. Therefore, clinicians have tried to apply rectum-preserving treatment strategies such as transanal local excision (LE) or the wait-and-see approach for nCRT-receiving patients who responded well [8,9,10,11,12,13,14,15,16,17,18,19,20]. Many previous studies reported that LE after nCRT showed oncologic outcomes similar to that of radical surgery [8,9,10,11,12,13,14,15]; however, no definite conclusions have been derived to date because of the limitations of retrospective study designs.…”
Section: Introductionmentioning
confidence: 99%
“…[22] Bothstrategies,localexcisionandclinicalobservationwithoutsurgery,areonlypossibleifthepredictionofresponseto radiochemotherapyissatisfying.Thisproblemhasbeenpublishedinlittleseriesinwhichupto75%ofthepatientswho wereclinicallyincompleteremissionhadhistopathologically detectable cancer cells. In other data, biopsies were taken from tumors but no cancer cells were detectable in the histopathologicalexamination [23,24].…”
Section: No Surgery After Full Remission During Neoadjuvant Radiochemmentioning
confidence: 99%