Chemopreventive potential of ferulic acid in 7,12-dimethylbenz[a]anthracene-induced mammary carcinogenesis in Sprague–Dawley rats

Baskaran, Nagarethinam; Manoharan, Shanmugam; Sadasivam, Balakrishnan; Pugalendhi, Pachaiappan

doi:10.1016/j.ejphar.2010.03.054

Cited by 82 publications

(56 citation statements)

References 35 publications

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“…The ferulic acidmediated reduction in colon adenomas and adenocarcinomas concurred with increases in GST and quinine reductase in the liver and colon of colon tumor-bearing rats in a ferulic acid dose-dependent manner . Similarly, oral administration of ferulic acid resulted in the normalization of cytochrome P450 and b 5 (Alias et al, 2009) and of SOD, catalase, glutathione peroxidase, GST, and GSH to control levels in the liver and skin of skin tumor-bearing mice (Alias et al, 2009) and in the plasma and mammary tissue of mammary tumor-bearing rats (Baskaran et al, 2010). These data suggest that in vivo, both phase I and II detoxifying enzymes may aid in the chemopreventive action of ferulic acid.…”

Section: B Pharmacokinetics and Pharmacodynamics Of Curcumin Catabolmentioning

confidence: 79%

The Molecular Basis for the Pharmacokinetics and Pharmacodynamics of Curcumin and Its Metabolites in Relation to Cancer

Golen²,

et al. 2013

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Section: B Pharmacokinetics and Pharmacodynamics Of Curcumin Catabolmentioning

confidence: 79%

The Molecular Basis for the Pharmacokinetics and Pharmacodynamics of Curcumin and Its Metabolites in Relation to Cancer

Golen²,

et al. 2013

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“…Plasma TBARS serves as a reliable marker to assess ROS mediated oxidative damage. Extensive studies reported an inverse association between TBARS and antioxidants in the plasma of tumor bearing animals (Manoharan et al, 2006;Baskaran et al, 2010). Increase in plasma TBARS could be either due to poor antioxidant defense system or due to overproduction of ROS in the body with subsequent leakage into plasma during cancerous conditions.…”

Section: Discussionmentioning

confidence: 99%

Anti-tumor Initiating Potential of Andrographolide in 7,12-dimethylbenz[a]anthracene Induced Hamster Buccal Pouch Carcinogenesis

Manoharan¹,

Singh²,

Suresh³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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The aim of the study was to investigate the chemopreventive potential of andrographolide in 7,12-dimethylbenz(a) anthracene (DMBA)-induced hamster buccal pouch carcinogenesis. Oral tumors developed in the buccal pouch of golden Syrian hamsters at a 100% incidence on painting with 0.5% DMBA in liquid paraffin three times a week for 14 weeks. Marked abnormalities in the status of detoxification enzymes, lipid perxodiation and antioxidants were noticed in hamsters treated with DMBA alone. Oral administration of andrographolide at a dose of 50 mg/ kg bw to hamsters treated with DMBA not only completely prevented the tumor formation but also restored the status of the above mentioned biomarkers. The present study thus demonstrates the chemopreventive potential of andrographolide in DMBA-induced hamster buccal pouch carcinogenesis, which is probably due to its antioxidant potential as well as modulating effect on xenobiotic metabolising enzymes during DMBA-induced oral carcinogenesis.

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“…Oral administration of FA at a dose of 40 mg/kg body weight prevented tumor formation in 80% of the rats (Baskaran et al, 2010). Although there is no detailed mechanism of the process, the modulatory effect of FA on the phase II detoxification cascade could play a possible role and it deserves attention due to its therapeutic potential in preventing mammary cancer.…”

Section: Anticarcinogenic Agentmentioning

confidence: 99%

Ferulic acid and derivatives: molecules with potential application in the pharmaceutical field

Brenelli

Goldbeck

Santos

et al. 2013

Braz. J. Pharm. Sci.

155

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Ferulic acid is a phenolic acid widely distributed in the plant kingdom. It presents a wide range of potential therapeutic effects useful in the treatments of cancer, diabetes, lung and cardiovascular diseases, as well as hepatic, neuro and photoprotective effects and antimicrobial and anti-inflammatory activities. Overall, the pharmaceutical potential of ferulic acid can be attributed to its ability to scavenge free radicals. However, recent studies have revealed that ferulic acid presents pharmacological properties beyond those related to its antioxidant activity, such as the ability to competitively inhibit HMG-CoA reductase and activate glucokinase, contributing to reduce hypercholesterolemia and hyperglycemia, respectively. The present review addresses ferulic acid dietary sources, the pharmacokinetic profile, antioxidant action mechanisms and therapeutic effects in the treatment and prevention of various diseases, in order to provide a basis for understanding its mechanisms of action as well as its pharmaceutical potential.Uniterms: Ferulic acid/properties. Ferulic acid/antioxidant activity. Ferulic acid/dietary sources. Ferulic acid/therapeutic effects. Natural products. Pharmacognosy.O ácido ferúlico é um ácido fenólico amplamente distribuído no reino vegetal. Ele apresenta uma ampla gama de potenciais efeitos terapêuticos utéis no tratamento do câncer, diabetes, doenças pulmonares e cardiovasculares, bem como efeitos hepáticos, neuro e fotoprotetores, atividades antimicrobianas e antiinflamatórias. O potencial farmacêutico do ácido ferúlico pode ser atribuído à sua capacidade em sequestrar radicais livres. No entanto, estudos recentes revelaram que o ácido ferúlico apresenta propriedades farmacológicas, além da sua atividade antioxidante, como a capacidade de inibir competitivamente a HMG-CoA redutase e ativar a glucoquinase, contribuindo para reduzir a hipercolesterolemia e hiperglicemia, respectivamente. A presente revisão aborda as fontes dietéticas de ácido ferúlico, o perfil farmacocinético, os mecanismos de ação como antioxidante e efeitos terapêuticos no tratamento e prevenção de várias doenças, de modo a proporcionar uma base para a compreensão dos seus mecanismos de ação, bem como os seus potenciais farmacêuticos.Unitermos: Ácido ferúlico/propriedades. Ácido ferúlico/atividade antioxidante. Ácido ferúlico/fontes dietéticas. Ácido ferúlico/efeitos terapêuticos. Produtos naturais. Farmacognosia. INTRODUCTIONNatural antioxidants exhibit therapeutic potential for a variety of diseases such as cancer, diabetes, and cardiovascular and neurodegenerative diseases (Kayahara et al., 1999;Kim et al., 2003;Soobrattee et al., 2005) where free radicals play a key role in development (Prior et al., 1998). Recently there has been increased public and scientific interest in employing natural antioxidants instead of synthetic antioxidants, due to their potential adverse effects on health which may include carcinogenicity (Ito et al., 1983;Würtzen, 1990;Osawa et al., 1990).Antioxidants found in vegetables can ac...

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Chemopreventive potential of ferulic acid in 7,12-dimethylbenz[a]anthracene-induced mammary carcinogenesis in Sprague–Dawley rats

Cited by 82 publications

References 35 publications

The Molecular Basis for the Pharmacokinetics and Pharmacodynamics of Curcumin and Its Metabolites in Relation to Cancer

The Molecular Basis for the Pharmacokinetics and Pharmacodynamics of Curcumin and Its Metabolites in Relation to Cancer

Anti-tumor Initiating Potential of Andrographolide in 7,12-dimethylbenz[a]anthracene Induced Hamster Buccal Pouch Carcinogenesis

Ferulic acid and derivatives: molecules with potential application in the pharmaceutical field

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