Chemokines in eosinophil-associated gastrointestinal disorders

Hogan, Simon P.; Rothenberg, Marc E.; Forbes, Elizabeth; Smart, V.E.; Matthaei, Klaus I.; Foster, Paul S.

doi:10.1007/s11882-004-0047-8

Cited by 28 publications

(32 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1). 38,49 The gastrointestinal tract is the main nonhematopoietic organ where eosinophils reside in the healthy state. Eosinophils are normally present in the lamina propria, but the number of eosinophils regarded as pathological for various sites along the gastrointestinal tract is debated; the highest concentrations are found in the cecum and appendix.…”

Section: The Eosinophilmentioning

confidence: 99%

Eosinophilic gastroenteritis: a review

Chetty

2008

J Gastroenterol

View full text Add to dashboard Cite

Eosinophilic gastroenteritis is a clinicopathological disease affecting both children and adults that is characterized by patchy or diffuse eosinophilic infiltration of the gastrointestinal tract with variable resultant clinical gastrointestinal manifestations. The eosinophil, eotaxin, and Th-2 cytokines are important in pathogenesis of this disease entity. It may be confused with parasitic and bacterial infections (including Helicobacter pylori), inflammatory bowel disease, hypereosinophilic syndrome, myeloproliferative disorders, periarteritis, allergic vasculitis, scleroderma, drug injury, and drug hypersensivity. Obtaining the correct diagnosis is important, and a pathologist usually makes this distinction. Effective treatments include systemic/topical corticosteroids, specific food elimination or an elemental diet, certain drugs, and even surgery. A variety of new therapeutic approaches are now under trial.

show abstract

Section: The Eosinophilmentioning

confidence: 99%

Eosinophilic gastroenteritis: a review

Chetty

2008

J Gastroenterol

View full text Add to dashboard Cite

show abstract

“…selectins and integrins) and integrin receptors (e.g. vascular cell adhesion molecule-1 [VCAM-1], mucosal addressin cell adhesion molecule-1 [MAdCAM-1] and intercellular adhesion molecule-1 [ICAM-1]) expressed on vascular endothelial cells [120, 121]. For example, eosinophil recruitment to the site of allergic inflammation in the lung and skin is regulated by VLA-4 (α 4 β 1 -integrin)/VCAM-1-dependent processes [122,123,124,125,126].…”

Section: Eosinophilic Gastrointestinal Diseases (Egid)mentioning

confidence: 99%

“…Our studies demonstrating a critical role of MAdCAM-1/α 4 β 7 -integrin-dependent pathway in eosinophil recruitment into the small intestine and ICAM-1/MAC-1 and LFA-1-pathways for recruitment into the large intestine suggest that differential adhesion systems regulate eosinophil recruitment into discrete GI compartments. Paradoxically, we have demonstrated that the recruitment of eosinophils into these various GI compartments (small and large intestine) is primarily regulated by eotaxin-1 [121]. How eotaxin-1 selectively recruits eosinophils into discrete GI compartments in the absence of other GI segment involvement remains to be determined.…”

Section: Eosinophilic Gastrointestinal Diseases (Egid)mentioning

confidence: 99%

Recent Advances in Eosinophil Biology

Hogan¹

2007

Int Arch Allergy Immunol

Self Cite

View full text Add to dashboard Cite

Eosinophils are pleiotropic multi-functional leukocytes involved in initiation and propagation of diverse inflammatory responses. Recent studies examining eosinophil biology have focused on delineating the molecular basis of FIP1L1/PDGRFα-fusion gene induced HES, the molecular steps involved in eosinophil recruitment in tumor-associated eosinophilia and EGID, and the role of eosinophils in asthma. In this review, these studies are summarized, focusing on the implications of these findings in the understanding the role of eosinophils in diseases.

show abstract

“…To elucidate the etiology of disease, we developed an experimental model oral antigen-induced eosinophilic GI inflammation that mimics EGE [39]. Oral administration of the antigen ovalbumin to OVA-sensitized mice induced a pronounced eosinophilic inflammation of the small intestine (duodenum, jejunum, and ileum).…”

Section: Experimental Eosinophilic Gastroenteritismentioning

confidence: 99%

“…Notably, eosinophils in the jejenum of oral antigen-challenged mice were in close proximity to damaged enteric nerves [39]. The enteric nerves contained swollen, enlarged axonal chambers with variable loss of internal organelles, including the dense core granules of Schwann cells.…”

Section: Experimental Eosinophilic Gastroenteritismentioning

confidence: 99%

Eosinophil function in eosinophil-associated gastrointestinal disorders

Hogan

Rothenberg²

2006

Curr Allergy Asthma Rep

Self Cite

View full text Add to dashboard Cite

Eosinophil-associated gastrointestinal disorders (EGIDs) are characterized by a rich eosinophilic inflammation of the gastrointestinal tract in the absence of known causes for eosinophilia or other gastrointestinal disorders. These disorders include eosinophilic esophagitis, eosinophilic gastritis, eosinophilic gastroenteritis, eosinophilic enteritis, and eosinophilic colitis, and are being recognized with increasing frequency. Clinical studies suggest that eosinophils have a pathogenic role in EGID; however, the function of eosinophils in these disorders remains an enigma. In this review, we briefly describe the clinical features of EGID of the esophagus, small bowel, and colon. We summarize recent experimental analysis examining the underlying contribution of eosinophils to disease pathogenesis and discuss possible therapeutic approaches for the treatment of these diverse diseases.

show abstract

Chemokines in eosinophil-associated gastrointestinal disorders

Cited by 28 publications

References 55 publications

Eosinophilic gastroenteritis: a review

Eosinophilic gastroenteritis: a review

Recent Advances in Eosinophil Biology

Eosinophil function in eosinophil-associated gastrointestinal disorders

Contact Info

Product

Resources

About