2018
DOI: 10.1042/bsr20180580
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Abstract: Chemokine (C-X-C motif) ligand 1 (CXCL1) is a chemotactic cytokine known to regulate cancer progression and invasion. However, the prognostic significance of CXCL1 expression in colorectal cancer (CRC) has not been fully characterized. The present study explored the clinicopathological significance and potential role of CXCL1 in the carcinogenesis and progression of CRC. The protein expression of CXCL1 was measured immunohistochemically in tissue microarrays constructed from 276 CRC patients. CXCL1 expression … Show more

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Cited by 47 publications
(45 citation statements)
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“…Clinically, the tissue microarray analysis of 276 patients with colon cancer indicated that CXCL1 played a vital role in the progression and metastasis of colon cancer [44]. The expression level of CXCL1 is an independent prognostic factor for both OS and DFS in patients with colon cancer [45]. Therefore, disrupting the TAMs/CXCL1 signaling to block PMN formation is emerging as a promising therapeutic approach for cancer metastasis.…”
Section: Discussionmentioning
confidence: 99%
“…Clinically, the tissue microarray analysis of 276 patients with colon cancer indicated that CXCL1 played a vital role in the progression and metastasis of colon cancer [44]. The expression level of CXCL1 is an independent prognostic factor for both OS and DFS in patients with colon cancer [45]. Therefore, disrupting the TAMs/CXCL1 signaling to block PMN formation is emerging as a promising therapeutic approach for cancer metastasis.…”
Section: Discussionmentioning
confidence: 99%
“…CXCL1 has been reported to play an important role in CRC progression and metastasis by inducing glycolysis [179]. CXCL1 is also an ELR + CXC chemokine that induces angiogenesis by binding to CXCR2 [109].…”
Section: Cxcl1mentioning
confidence: 99%
“…Neutrophils also promote metastasis by releasing cytokines and associating with circulating tumor cells [45][46][47]. In in vivo cancer models, the inhibition of CXCR2 reduces neutrophil recruitment to tumors and increases the efficacy of chemotherapy [44,48,49]. The progression inhibitors of tumor tissues targeting TINs so just focused on inhibiting TINs recruitment.…”
Section: Discussionmentioning
confidence: 99%