Chemoenzymatic Synthesis and Anti-Inflammatory Activity of Fatty Acid Amides Prepared from Bertholletia excelsa (Brazil Nut) Triglycerides

Barata, Pedro C.; Sarquis, Ícaro Rodrigues; Carvalho, Helison de Oliveira; Barros, Albenise Santana Alves; Rodrigues, Alex Bruno Lobato; Galué-Parra, Adan; Silva, Edilene O.; Carvalho, José Carlos Tavares; Ferreira, Irlon M.

doi:10.21577/0103-5053.20200041

Cited by 2 publications

(34 citation statements)

References 27 publications

(34 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The band at 3013 cm −1 was attributed to the C-H stretching vibration of the unsaturated fatty acids. The high-intensity peaks at 2934 cm −1 and 2848 cm −1 are due to asymmetric and symmetric aliphatic C-H stretchings, respectively [23]. The strong absorption band at 1754 cm −1 is assigned to the stretching vibration of the ester carbonyl group in the triglycerides.…”

Section: Fourier Transform Infrared Spectroscopy Analysismentioning

confidence: 96%

“…However, based on Amazon biodiversity, numerous advances have been made in recent years to demonstrate the health benefits of oils from Amazon, and among these, B. excelsa seed oil stands out. The oils extracted from the seed of B. excelsa show notable high nutritional value and several biological activities, such as healing, antioxidant, and anti-inflammatory activities [21][22][23]. Furthermore, this oil has a high stearic acid content and low concentration of other saturated fats, excellent characteristics for the oil phase in the preparation of NLCs [24].…”

Section: Fatty Acid Composition Of the Vegetable Oilsmentioning

confidence: 99%

Green Extraction of Annatto Seed Oily Extract and Its Use as a Pharmaceutical Material for the Production of Lipid Nanoparticles

et al. 2022

Self Cite

View full text Add to dashboard Buy / Rent full text

This work developd nanomaterials formulated from annatto seed oily extract (ASE), myristic acid (tetradecanoic acid), and their fatty acid esters. The annatto seed oily extract was obtained using only soybean oil (ASE + SO) and Brazil nut oil (ASE + BNO). The UV/VIS analysis of the oily extracts showed three characteristic peaks of the bixin molecule at 430, 456 and 486 nm. The lipid nanoparticles obtained using myristic acid and ASE + BNO or only BNO showed better results than the oil soybean extract, i.e., the particle size was <200 nm, PDI value was in the range of 0.2–0.3, and had no visual physical instability as they kept stable for 28 days at 4 °C. Lipid nanoemulsions were also produced with esters of myristic acid and ASE + BNO. These fatty acid esters significantly influenced the particle size of nanoemulsions. For instance, methyl tetradecanoate led to the smallest particle size nanoemulsions (124 nm), homogeneous size distribution, and high physical stability under 4 and 32 °C for 28 days. This work demonstrates that the chemical composition of vegetable oils and myristic acid esters, the storage temperature, the chain length of fatty acid esters (FAE), and their use as co-lipids improve the physical stability of lipid nanoemulsions and nanoparticles from annatto seed oily extract.

show abstract

“…The fatty acids of Patawa oil ( Oenocarpus bataua ), have also been submitted to the amidation process, with the major products being the endocannabinoid analogs N-isopropylpalmitamide and N-isopropyloleamide [ 95 ]. Oils extracted from Bertholletia excelsa (Brazil nut) have also been a substrate for the production of endocannabinoid analogs using lipase from Pseudomonas fluorescens , with a yield of up to 95% after reaction [ 98 ].…”

Section: Endocannabinoids From Plant Oilsmentioning

confidence: 99%

The GABAergic System and Endocannabinoids in Epilepsy and Seizures: What Can We Expect from Plant Oils?

Oliveira¹,

Silva²,

Hamoy³

et al. 2022

Molecules

Self Cite

View full text Add to dashboard Buy / Rent full text

Seizures and epilepsy are some of the most common serious neurological disorders, with approximately 80% of patients living in developing/underdeveloped countries. However, about one in three patients do not respond to currently available pharmacological treatments, indicating the need for research into new anticonvulsant drugs (ACDs). The GABAergic system is the main inhibitory system of the brain and has a central role in seizures and the screening of new ACD candidates. It has been demonstrated that the action of agents on endocannabinoid receptors modulates the balance between excitatory and inhibitory neurotransmitters; however, studies on the anticonvulsant properties of endocannabinoids from plant oils are relatively scarce. The Amazon region is an important source of plant oils that can be used for the synthesis of new fatty acid amides, which are compounds analogous to endocannabinoids. The synthesis of such compounds represents an important approach for the development of new anticonvulsant therapies.

show abstract

Chemoenzymatic Synthesis and Anti-Inflammatory Activity of Fatty Acid Amides Prepared from Bertholletia excelsa (Brazil Nut) Triglycerides

Cited by 2 publications

References 27 publications

Green Extraction of Annatto Seed Oily Extract and Its Use as a Pharmaceutical Material for the Production of Lipid Nanoparticles

The GABAergic System and Endocannabinoids in Epilepsy and Seizures: What Can We Expect from Plant Oils?

Contact Info

Product

Resources

About