Chemistry of South African Lamiaceae: Structures and Biological Activity of Terpenoids

Hussein, Ahmed A.

doi:10.5772/intechopen.77399

Cited by 6 publications

(11 citation statements)

References 93 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Most of the species are herbaceous or shrubby, and trees are scarce. The most well-known genus is Salvia (900), followed by Scutellaria (360), Stachys (300), Plectranthus (300), Hyptis (280), Teucrium (250), Vitex (250), Thymus (220), Nepeta (200), and Clerodendrum (150) [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Potential Application of Some Lamiaceae Species in the Management of Diabetes

Etsassala

Hussein

Nchu

2021

Plants

View full text Add to dashboard Cite

Diabetes is one of the most dangerous metabolic disorders, with high rates of mortality worldwide. Since ancient times, medicinal plants have been used in traditional medicine to treat many diseases, including diabetes and its related complications. Plants are widely accepted, affordable, and perceived to have minimal adverse side effects. The Lamiaceae family is a potential source of therapeutic agents for the management of metabolic disorders, including diabetes. Hence, this review paper summarizes the antidiabetic use of Lamiaceae species in folk medicine globally. Furthermore, we present the antidiabetic activities and phytochemical constituents of twenty-three (23) Lamiaceae species and the antidiabetic activity of some notable chemical constituents isolated from some of these Lamiaceae species.

show abstract

Section: Introductionmentioning

confidence: 99%

Potential Application of Some Lamiaceae Species in the Management of Diabetes

Etsassala

Hussein

Nchu

2021

Plants

View full text Add to dashboard Cite

show abstract

“…28 Many of these diseases are caused by bacterial infections and numerous studies have reported antibacterial properties for species of this genus. [41][42][43] However, many of these studies either do not quantify the activity, or report low to moderate activity for the extracts and oils of these plants.…”

Section: Discussionmentioning

confidence: 99%

Westringa fruticosa (Willd.) Druce Leaf and Flower Extracts Lack Antibacterial Activity and are Non-toxic in vitro

Chikowe¹,

Mpala²,

Cock³

2019

View full text Add to dashboard Cite

Introduction: Closely related plant species often share similar secondary metabolites and bioactivities and are therefore good targets for bioactivity testing when one or more species within a family are known to possess therapeutic properties. The family Laminaceae has a long history of medicinal usage globally. Many species are known to have therapeutic properties, several species of which have well established antibacterial bioactivities. Methods: The ability of Westringa fruticosa leaf and flower extracts to inhibit the growth of a panel of bacterial and fungal pathogens was investigated by disc diffusion assay. Toxicity was examined using the Artemia franciscana nauplii bioassay. Results: W. fruticosa leaf methanolic and aqueous extracts were both completely ineffective at inhibiting the growth of gram-positive and gram-negative panels of bacteria, as well as fungi. The extracts were non-toxic or of low toxicity in the Artemia bioassay following 24 h exposure. Conclusion: Despite the taxonomic relationship to several bioactive Laminaceae spp., W. fruticosa leaf and flower extracts were completely ineffective bacterial and fungal growth inhibitors. However, these extracts may have other therapeutic properties and testing against protozoa, virus and tumour cells is required.

show abstract

“…However, the lack of chromatographic data and reference compounds limits their use in such useful applications [ 314 ]. In a review by Hussein (2018) [ 210 ], a thorough account of the diterpenoids isolated from southern African species, especially from the genera Coleus , Leonotis , Plectranthus , Salvia , and Tetradenia, is presented.…”

Section: Chemical Compoundsmentioning

confidence: 99%

“…Paton. Compounds such as coleon U and V, royleanone and horminone were identified from C. grandidentatus with coleon U exhibiting potent cytotoxicity against human cancer cell lines and has been deemed a promising anticancer compound needing further investigation [ 210 ]. Coleus comosus has been well studied with twenty compounds identified, eleven of which are neoclerodanes, seven labdanes and several abietanes [ 210 ].…”

Section: Chemical Compoundsmentioning

confidence: 99%

“…Compounds such as coleon U and V, royleanone and horminone were identified from C. grandidentatus with coleon U exhibiting potent cytotoxicity against human cancer cell lines and has been deemed a promising anticancer compound needing further investigation [ 210 ]. Coleus comosus has been well studied with twenty compounds identified, eleven of which are neoclerodanes, seven labdanes and several abietanes [ 210 ]. Two abietane diterpenoids were isolated for the first time from C. madagascariensis (7β-acetoxy-6β-hydroxyroyleanone and 7β,6β-dihydroxyroyleanone), along with rosmarinic acid and coleon U quinone, all of which exhibited inhibitory activity on α-glucosidase with IC 50 values ranging from 33 to 275 µM [ 102 ].…”

Section: Chemical Compoundsmentioning

confidence: 99%

See 1 more Smart Citation

The Botanical, Chemical and Ethnobotanical Diversity of Southern African Lamiaceae

Rattray

Wyk

2021

Molecules

View full text Add to dashboard Cite

The Lamiaceae is undoubtedly an important plant family, having a rich history of use that spans the globe with many species being used in folk medicine and modern industries alike. Their ability to produce aromatic volatile oils has made them valuable sources of materials in the cosmetic, culinary, and pharmaceutical industries. A thorough account of the taxonomic diversity, chemistry and ethnobotany is lacking for southern African Lamiaceae, which feature some of the region’s most notable medicinal and edible plant species. We provide a comprehensive insight into the Lamiaceae flora of southern Africa, comprising 297 species in 42 genera, 105 of which are endemic to the subcontinent. We further explore the medicinal and traditional uses, where all genera with documented uses are covered for the region. A broad review of the chemistry of southern African Lamiaceae is presented, noting that only 101 species (34%) have been investigated chemically (either their volatile oils or phytochemical characterization of secondary metabolites), thus presenting many and varied opportunities for further studies. The main aim of our study was therefore to present an up-to-date account of the botany, chemistry and traditional uses of the family in southern Africa, and to identify obvious knowledge gaps.

show abstract

Chemistry of South African Lamiaceae: Structures and Biological Activity of Terpenoids

Cited by 6 publications

References 93 publications

Potential Application of Some Lamiaceae Species in the Management of Diabetes

Potential Application of Some Lamiaceae Species in the Management of Diabetes

Westringa fruticosa (Willd.) Druce Leaf and Flower Extracts Lack Antibacterial Activity and are Non-toxic in vitro

The Botanical, Chemical and Ethnobotanical Diversity of Southern African Lamiaceae

Contact Info

Product

Resources

About