volume 277, issue 1-2, P133-139 2004
DOI: 10.1016/j.ijpharm.2003.06.002
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Abstract: Most polymeric implants are biodegraded by one of two common chemical degradation mechanisms: (i). hydrolysis and (ii). oxidation. The chemical structure is among the most important factors which affect the biodegradation of polymeric implants. Hydrolytic biodegradations are often accompanied by substantial decrease of pH, whilst oxidative biodegradation processes are usually very slow due to consumption of stoichiometric amounts of oxidising agents. A dramatic acceleration of the biodegradation can be expecte…

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