Chemistry of Enaminonitriles of Pyrano[2,3-c]pyrazole and Related Compounds

Efficient Syntheses of Some New Thiophene‐Based Heterocycles

“…Enaminonitriles are versatile reagents, and their chemistry has recently received a considerable attention as precursors to, otherwise not readily obtainable heteroaromatics . We have recently reviewed the chemistry of the synthesis and application of heterocycles derived from enaminonitriles . For this purpose, compound ( 2 ) reacted with piperidine, as N ‐nucleophile, in refluxing ethanol to afford the corresponding acyclic adduct ( 9 ).…”

Reactivity of 2‐Thiazolylhydrazonomalononitrile toward Carbon and Nitrogen Nucleophilic Reagents: Applications to the Synthesis of New Heterocycles

“…Enaminonitriles are versatile reagents, and their chemistry has recently received considerable attention as precursors to otherwise not readily obtainable heteroaromatics . We have recently reviewed the chemistry of the synthesis and application of heterocycles derived from enaminonitriles . With this context, compound 1 reacted with piperidine in refluxing ethanol to afford the corresponding acyclic adduct 15 , which can exist in two tautomeric imino–amino forms ( 15A and 15B ; Scheme ).…”

Preparation, characterization and catalytic application of molybdenum Schiff‐base complex immobilized on silica‐coated Fe3O4 as a reusable catalyst for the synthesis of pyranopyrazole derivatives

“…Substituted pyranopyrazoles are much sought after class of heterocyclic compounds, which play a significant role in pharmaceutical field and biologically active compounds. [1][2][3] These compounds possess a variety of therapeutic and biological activities, for instance antiinflammatory, [4] antimicrobial, [5] anticancer, [6] inhibitors of human Chk1 kinase, [7] and analgesic. [8] Synthetic strategies of substituted pyrano [2,3-c] pyrazoles have evolved a long way from the early multistep protocols [1,[9][10][11] to present-day multicomponent reactions.…”

“…In recent years, there has been intense research on fused heterocyclic compounds with pharmacological importance. Substituted pyranopyrazoles are much sought after class of heterocyclic compounds, which play a significant role in pharmaceutical field and biologically active compounds . These compounds possess a variety of therapeutic and biological activities, for instance anti‐inflammatory, antimicrobial, anticancer, inhibitors of human Chk1 kinase, and analgesic .…”

“…These compounds possess a variety of therapeutic and biological activities, for instance anti‐inflammatory, antimicrobial, anticancer, inhibitors of human Chk1 kinase, and analgesic . Synthetic strategies of substituted pyrano[2,3‐c] pyrazoles have evolved a long way from the early multistep protocols to present‐day multicomponent reactions. Multi‐component reactions (MCRs) increase intrinsic atom economy, structural diversity, simplicity and synthetic efficiency on the conventional organic synthesis .…”