Chemistry of Anticonvulsant Drugs

Major advances in epilepsy in the last century: A personal perspective

“…Although Locock (1857) described using bromides to treat epilepsy, and Hauptmann (1912) introduced phenobarbital, the six papers related to the development of sodium diphenyl hydantoinate (phenytoin) published by Merritt between 1937 and1941 forever transformed the treatment of epilepsy and the development of antiepileptic drugs (Putnam & Merritt, 1937;Merritt & Putnam, 1938a, 1938b, 1939, 1940Putnam & Merritt, 1941. Rowland (1982 summarized their monumental achievements as follows:…”

Major advances in epilepsy in the last century: A personal perspective

“…Although Locock (1857) described using bromides to treat epilepsy, and Hauptmann (1912) introduced phenobarbital, the six papers related to the development of sodium diphenyl hydantoinate (phenytoin) published by Merritt between 1937 and1941 forever transformed the treatment of epilepsy and the development of antiepileptic drugs (Putnam & Merritt, 1937;Merritt & Putnam, 1938a, 1938b, 1939, 1940Putnam & Merritt, 1941. Rowland (1982 summarized their monumental achievements as follows:…”

dl-GLUTAMIC ACID HYDROCHLORIDE IN TREATMENT OF PETIT MAL AND PSYCHOMOTOR SEIZURES

“…three times a day. Larger doses, Read before the American Psychiatric Association, Detroit, May 10,1943 administration of the drug in dilute solution or capsules was seldom associated with gastric distress. Anti¬ convulsant therapy, though ineffective, was continued throughout the trial period.…”

Major advances in epilepsy in the last century: A personal perspective

“…Although Locock (1857) described using bromides to treat epilepsy, and Hauptmann (1912) introduced phenobarbital, the six papers related to the development of sodium diphenyl hydantoinate (phenytoin) published by Merritt between 1937 and1941 forever transformed the treatment of epilepsy and the development of antiepileptic drugs (Putnam & Merritt, 1937;Merritt & Putnam, 1938a, 1938b, 1939, 1940Putnam & Merritt, 1941. Rowland (1982 summarized their monumental achievements as follows:…”

dl-GLUTAMIC ACID HYDROCHLORIDE IN TREATMENT OF PETIT MAL AND PSYCHOMOTOR SEIZURES

“…three times a day. Larger doses, Read before the American Psychiatric Association, Detroit, May 10,1943 administration of the drug in dilute solution or capsules was seldom associated with gastric distress. Anti¬ convulsant therapy, though ineffective, was continued throughout the trial period.…”

Major advances in epilepsy in the last century: A personal perspective

“…Although Locock (1857) described using bromides to treat epilepsy, and Hauptmann (1912) introduced phenobarbital, the six papers related to the development of sodium diphenyl hydantoinate (phenytoin) published by Merritt between 1937 and1941 forever transformed the treatment of epilepsy and the development of antiepileptic drugs (Putnam & Merritt, 1937;Merritt & Putnam, 1938a, 1938b, 1939, 1940Putnam & Merritt, 1941. Rowland (1982 summarized their monumental achievements as follows:…”

dl-GLUTAMIC ACID HYDROCHLORIDE IN TREATMENT OF PETIT MAL AND PSYCHOMOTOR SEIZURES

“…three times a day. Larger doses, Read before the American Psychiatric Association, Detroit, May 10,1943 administration of the drug in dilute solution or capsules was seldom associated with gastric distress. Anti¬ convulsant therapy, though ineffective, was continued throughout the trial period.…”