ChemInform Abstract: α,β DEHYDROGENATION OF CARBOXAMIDES

Abstract

Es wird eine allgemein anwendbare, unter milden Bedingungen als Eintopf‐Reaktion verlaufende Dehydrierung von sek.‐Carbon‐ säureamiden beschrieben.

Chemoselective α-Sulfidation of Amides Using Sulfoxide Reagents

“…Innovative reports continue to demonstrate the practical nature of this approach to amide derivatization. 9 , 10 Inspired by observations on the addition of pyridine N -oxides to activated amides, 11 as in our modified Abramovitch reaction that leads to carbon–nitrogen bond formation, 5e and the use of sulfoxides in carbon–carbon bond formation, 9j we envisioned the use of sulfoxide reagents for carbon–sulfur bond formation. Sulfoxides are readily available, easily derivatized, and bench stable in comparison with noxious thiols and can serve as both an oxidant and a sulfur source.…”