volume 30, issue 43, Pno-no 2010
DOI: 10.1002/chin.199943277
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P. Prasit,
Z. Wang,
et al. et al.

Abstract: 1999 pharmacology, medicinal chemistry, vaccines, serums pharmacology, medicinal chemistry, vaccines, serums V 1100 -277The Discovery of Rofecoxib, [MK 966, Vioxx r , 4-(4'-Methylsulfonylphenyl)-3-phenyl-2(5H)-furanone], an Orally Active Cyclooxygenase-2 Inhibitor.-The discovery and development of the title compound (Ia) is described, a COX-2 inhibitor based on the 4methylsulfonylphenyl series. This compound shows the best overall profile, it is essentially equipotent to indomethacin both in vitro and in vivo…

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