volume 30, issue 43, Pno-no 2010
DOI: 10.1002/chin.199943208
View full text
|
|
Share
Ulf Berg, Hakan Bladh

Abstract: Dedicated to the memory of Prof. Vladimir PrelogThe absolute configuration of natural (À)-colchicine is (aR,7S) Colchicine, 1, the principal alkaloid from Colchicum autumnale, is a well-known antimitotic drug, which has been extensively studied for many years. The molecular structure of colchicine was first suggested by Dewar [1]. The structure was firmly established a few years later by chemical degradation [2], X-ray analysis [3], and confirmed by several total syntheses, first by Eschenmoser and co-work…

Expand abstract