Dedicated to the memory of Prof. Vladimir PrelogThe absolute configuration of natural (À)-colchicine is (aR,7S) Colchicine, 1, the principal alkaloid from Colchicum autumnale, is a well-known antimitotic drug, which has been extensively studied for many years. The molecular structure of colchicine was first suggested by Dewar . The structure was firmly established a few years later by chemical degradation , X-ray analysis , and confirmed by several total syntheses, first by Eschenmoser and co-work…
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