volume 30, issue 42, Pno-no 2010
DOI: 10.1002/chin.199942255
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Isabelle Billault, Andrea Vasella

Abstract: The analogues 1 ± 3 of dolichol monophosphatidyl b-d-glucose have been prepared as potential inhibitors of the glucosyl transferase Alg10p. Pd(PPh 3 ) 4 -catalysed phosphonylation of the iodoimidazole 4 with diethyl, dimethyl, and diphenyl phosphite led to the corresponding phosphonic acid diesters, which were transformed into deprotected and silyl-protected diesters, deprotected monoesters, and protected and unprotected phosphonic acids (Scheme). A N-methyl imidazolium salt was obtained as a by-product of th…

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