ChemInform Abstract: Synthesis, Characterization and Antimicrobial Activity of Some 3‐(2‐(1H‐Benzo[d]imidazol‐2‐yl)phenyl)‐2‐arylthiazolidin‐4‐ones.

Desai, N. C.; Bhatt, Nayan; Kumar, Mahesh; Makwana, Atul H.

doi:10.1002/chin.201145122

Cited by 1 publication

(2 citation statements)

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“…The MICs of 6 compounds illustrated good activity, especially compounds 3B, 3E, and 3H with MICs of ≤8 mg/mL for S. aureus and MRSA, compared with the positive control, and novel compounds in previous studies [9][10][11]20]. Therefore, these compounds can be further investigated in the quest for new antimicrobial agents.…”

Section: Antimicrobial Activitymentioning

confidence: 81%

“…This structure has been acknowledged as a powerful pharmacophore because of its therapeutic effects on almost all kinds of diseases [4]. Some notable actions of thiazolidin-4-one are antiproliferative [5], anti-HIV [6], antioxidant [7], anticonvulsant [8], and antimicrobial [9][10][11][12][13] effects. An aryl substitution at position 5 of thiazolidin-4-one can dramatically increase the potency of pharmacological effects [4].…”

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confidence: 99%

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Antimicrobial activity of some novel 2-(2-iodophenylimino)-5-arylidenethiazolidin-4-one derivatives

Phạm

Phuong

et al. 2017

Asian Biomedicine

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Background Infectious diseases, especially those caused by multidrug-resistant bacteria, are becoming a serious problem worldwide because of the lack of effective therapeutic agents. Moreover, most antifungal drugs exhibit low efficacy and high toxicity because of the similarity between fungal and human cells. These issues warrant the search for potential new agents. Objectives To synthesize potent 2-(2-iodophenylimino)-5-arylidenethiazolidin-4-one derivatives, improve the synthetic process, elucidate their structures, and determine their antimicrobial activity. Methods 2-Iodoaniline was used as an initial reactant in a 3-step process for the synthesis of 2-(2-iodophenylimino)-5-arylidenethiazolidin-4-one derivatives, including an acylation reaction, a cyclization reaction, and aldol condensation reactions. The structures of the obtained derivatives were investigated and elucidated using spectral methods. Antimicrobial activity toward 5 bacterial strains and 2 fungal strains was determined using Kirby–Bauer and agar dilution methods. Results We successfully synthesized 12 novel compounds and elucidated their structures. The derivatives had no antifungal activities. By contrast, they showed remarkable antibacterial activities. Some of them with minimum inhibitory concentrations (MICs) ≤8 μg/mL in both Staphylococcus aureus and methicillin-resistant S. aureus. Conclusions A simple and flexible way to synthesize new compounds with a thiazolidin-4-one ring was determined. Some of these new compounds have outstanding effects with low MICs for bacteria. Their further investigation as therapeutic agents is warranted.

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Section: Antimicrobial Activitymentioning

confidence: 81%

mentioning

confidence: 99%