John N. Freskos, Joseph J. McDonald, Brent V. Mischke, Patrick B. Mullins, Huey-Sheng Shieh, Roderick A. Stegeman, Anna M. Stevens
1999sulfoxides, sulfones, sulfenes and derivatives sulfoxides, sulfones, sulfenes and derivatives (benzene compounds) Q 0600
-092Synthesis and Identification of Conformationally Constrained Selective MMP Inhibitors.-Cyclic thiol based MMP inhibitors like (IV) are discovered. Reduction of the intermediate β-keto-sulfide leads to a 3:1 ratio of alcohols with the equatorial isomer as the major one. The thiols (V) are prepared using the same procedure as for the preparation of the corresponding acyclic thiols. Th…
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