ChemInform Abstract: SYNTHESIS AND BIOLOGICAL ACTIVITY OF N‐O‐CARBOXYPHENYLAMIDES OF β‐N1‐ARENESULFOHYDRAZIDE OF OXALIC ACID

Abstract

4‐Substituierte Benzolsulfonsäurechloride (I) reagieren mit dem Oxalsäurehydrazid‐amid (II) zu den Arylsulfonylhydraziden (III).

Microwave-assisted synthesis of benzenesulfonohydrazide and benzenesulfonamide cyclic imide hybrid molecules and their evaluation for anticancer activity

“…Sulfonohydrazide, sulfonamide and cyclic imide derivatives are examples of such novel molecules reported to exhibit anticancer activities (Arkinstall et al, 2001;Kendall et al, 2007;Cheng et al, 2014;Amin et al, 2013;Wang et al, 2014;Ghorab et al, 2014a, b;Jia et al, 2014;Machado et al, 2011Machado et al, , 2013Seliga et al, 2013;Li et al, 2009). Apart from anticancer activity, sulfonohydrazide, sulfonamide and cyclic imide derivatives are also reported to exhibit anti-inflammatory (Choi et al, 1995;Keche et al, 2012;Bock et al, 2006), antifungal (Dixit et al, 2010;Ezabadi et al, 2008;West and Cornell, 1998), antibacterial (Frlan et al, 2011;Dragostin et al, 2013;Prado et al, 2004), antimicrobial (Mahmoud et al, 2010;Kumar et al, 2014a;Al-Salahi et al, 2010), antioxidant (Sirajuddin et al, 2013;Mahdavi et al, 2014;Gul et al, 2013) and hypoglycemic (Bezuglyi et al, 1979;Faidallah and Khan, 2012;Abdel-Aziz et al, 2011) activities. In light of the above discussion, it was considered worthwhile to synthesize hybrid molecules of the above three types of heterocyclic molecules and analyze their anticancer activity.…”