volume 30, issue 43, Pno-no 2010
DOI: 10.1002/chin.199943264
View full text
|
|
Share
Isobel Bennett, Nigel J. P. Broom, Robert Cassels, John S. Elder, Nicky D. Masson, Peter J. O'Hanlon

Abstract: Synthesis and Antibacterial Properties of β-Diketone Acrylate Bioisosteres of Pseudomonic Acid A. -Fourteen bioisosteres like (V) and (IX) are synthesized and evaluated for their antibacterial activities. The first synthesis of the diketone system (V) uses a base-catalyzed deconjugation process. The second synthesis of system (IX) is complementary to that of system (V) and the ready availability of aldehydes (VII) makes this synthesis the preferred sequence. Optimal activity is observed with small para-phenyl…

expand abstract