ChemInform Abstract: Reaction of N‐Alkyl/Aralkylisatoic Anhydrides with Aroylhydrazines: Formation of 1,3,4‐Oxadiazoles and 1,4‐Dihydro‐5H‐1,3,4‐benzotriazepin‐5‐one.

Abstract

The reaction of the anhydrides (I) with aroylhydrazines such as (II) under the conditions shown gives products of type (III).

Synthesis, in vivo and in silico evaluation of novel 2,3‐dihydroquinazolin‐4(1H)‐one derivatives as potential anticonvulsant agents

“…M.p. 188–192°C as reported (Ibrahim, Abo‐Kul, Soltan, Barkat, & Helal, ; Reddy, Reddy, & Ratnam, ; Reddy & Reddy, ). 1 H NMR (DMSO, d 6 ) δ 2.80 (3H, d, J = 4.9, NCH 3 ), 6.61 (1H, t, J = 7.4, ph H), 6.69 (1H, d, J = 8.4, ph H), 7.36 (1H, t, J = 7.7, ph H), 7.51–7.60 (4H, m, ph H + NH), 7.68 (1H, d, J = 6.9, ph H), 7.93 (2H, d, J = 7.2, ph H), 10.24 (1H, s, NHCO), 10.39 (1H, s, NHCO).…”

“…M.p. 176–178°C as reported (Reddy et al, ; Reddy & Reddy, ). 1 H NMR (DMSO, d 6 ) δ 2.78 (3H, d, J = 5, NCH 3 ), 3.53 (2H, s, CH 2 CO), 6.56 (1H, t, J = 7.5, ph H), 6.66 (1H, d, J = 8.3, ph H), 7.24–7.34 (6H, m, ph H + NH), 7.48 (1H, d, J = 4.7, ph H), 7.58 (1H, d, J = 6.8, ph H), 10.05 (1H, s, NHCO), 10.08 (1H, s, NHCO).…”

“…M.p. 188-192 C as reported (Ibrahim, Abo-Kul, Soltan, Barkat, & Helal, 2014;Reddy, Reddy, & Ratnam, 1988; To a suspension of benzohydrazide (3a or 3b, 0.01 mol) in ethanol (50 mL) , 40% formalin or acetaldehyde (0.015 mol) and a few drops of glacial acetic acid were added. The reaction mixture was heated at reflux for 12 h and then concentrated to half the initial volume.…”