ChemInform Abstract: Phosphoinositide‐Regulated Kinases and Phosphoinositide Phosphatases

Leslie, Nicholas R.; Biondi, Ricardo M.; Alessi, Dario R.

doi:10.1002/chin.200140291

Cited by 1 publication

(1 citation statement)

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“…While PTEN transforms the AKT activator PI-(3,4,5)-P3 into PI-(4,5)-P2, SHIPs dephosphorylate PI-(3,4,5)-P3 to PI-(3,4)-P2. The expression of SHIP1 is largely restricted to hematopoietic cells, while SHIP2 appears to be more widely expressed [90,95]. Another component of negative regulation of the AKT signaling is carboxyl-terminal modulator protein C (CTMP).…”

Section: Pi3k/akt Negative Regulationmentioning

confidence: 99%

Molecular Pathways Involved in the Development of Congenital Erythrocytosis

Tomc

Debeljak

2021

Genes

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Patients with idiopathic erythrocytosis are directed to targeted genetic testing including nine genes involved in oxygen sensing pathway in kidneys, erythropoietin signal transduction in pre-erythrocytes and hemoglobin-oxygen affinity regulation in mature erythrocytes. However, in more than 60% of cases the genetic cause remains undiagnosed, suggesting that other genes and mechanisms must be involved in the disease development. This review aims to explore additional molecular mechanisms in recognized erythrocytosis pathways and propose new pathways associated with this rare hematological disorder. For this purpose, a comprehensive review of the literature was performed and different in silico tools were used. We identified genes involved in several mechanisms and molecular pathways, including mRNA transcriptional regulation, post-translational modifications, membrane transport, regulation of signal transduction, glucose metabolism and iron homeostasis, which have the potential to influence the main erythrocytosis-associated pathways. We provide valuable theoretical information for deeper insight into possible mechanisms of disease development. This information can be also helpful to improve the current diagnostic solutions for patients with idiopathic erythrocytosis.

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Section: Pi3k/akt Negative Regulationmentioning

confidence: 99%