ChemInform Abstract: New Pyrazolo[3,4‐b]pyrazines: Synthesis and Biological Activity.

Hs, el-Kashef; Ti, el-Emary; Gasquet, M.; Timon‐David, P.; Maldonado, José; Vanelle, Patrice

doi:10.1002/chin.200047151

Cited by 34 publications

(49 citation statements)

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“…Some of its derivatives are important as anticancer agents with low toxicity 12 , anti-inflammatory 13 , blood platelet aggregation inhibitors, bone metabolism improvers, adenosine antagonists and controlling herbicides 14 . They also show antifungal and antiparasitic activities 15 . In addition, they are used as disperse dyes and as fluorescents.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial, Antifungal, Anti-Oxidant, Anti-Inflammatory and Anti-Hypertensive Activities of N-Chloropyrazinamide

Vaijayanthi¹,

Mathiyalagan²

2014

ILCPA

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N-chloropyrazinamide was prepared by the chlorination of pyrazinamide using trichloroisocyanuric acid. The experimental results ascertained that the tested N-chloropyrazinamide showed good antimicrobial activities when compared to standard drug. It was found that Nchloropyrazinamide at different concentrations exhibited significant dose dependent anti-oxidant, anti-inflammatory and anti-hypertensive activity.

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Section: Introductionmentioning

confidence: 99%

Antibacterial, Antifungal, Anti-Oxidant, Anti-Inflammatory and Anti-Hypertensive Activities of N-Chloropyrazinamide

Vaijayanthi¹,

Mathiyalagan²

2014

ILCPA

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“…6 They also show antimicrobial and antiparasitic activities. 7,8 Also, pyrazoline derivatives have been found to possess antifungal, 9 antidepressant [10][11][12][13] anticonvulsant, 12,13 antiinflammatory, 14 antibacterial 15 and anti-tumor 16 activities. Chromenopyrazoles exhibit high activity against gram positive and gram negative bacteria.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and antimicrobial evaluation of some new pyrazole, pyrazoline and chromeno[3,4-c]pyrazole derivatives

Abunada

Hassaneen

Samaha

et al. 2009

J. Braz. Chem. Soc.

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Alguns novos derivados de pirazol-5-carbonitrila 8,9 e pirazol-5-carboxamida 13 foram sintetizados pela reação de cicloadição de nitriliminas 3,4 a α-cianocinamonitrilas 5a-f e α-cianocinamamida 12a,b, respectivamente. Por outro lado, a adição de 3,4 a α-cianocinamato de etila 14a-f leva à produção de derivados de 2-pyrazoline-5-carboxilato de etila, 15, 16. Também, a cicloadição de 3,4 à 3-cianocumarina 19a ou à 3-fenilsulfonilcumarina 19b ou à 3-bromocumarina 19c leva à produção de derivados do cromeno[3,4-c]pirazol-4(3H)-ona, 20. A cicloadição de 3,4 à 3-acetilcumarina, 22 e 3-benzoilcumarina, 23, produz o correspondente diidrocromeno [3,4-c] pirazol-4(3H)-ona, 24 e 25, respectivamente. A oxidação de 24 e 25 produz 20. A maioria dos compostos preparados mostrou boa a moderada atividade antibacteriana e antifúngica.Some new pyrazole-5-carbonitrile derivatives 8,9 and pyrazole-5-carboxamide 13 were synthesized by the cycloaddition reaction of nitrilimines 3,4 to α-cyanocinnamonitriles 5a-f and α-cyanocinnamamide 12a,b respectively. On the other hand 3,4 add to ethyl α-cyanocinnamate 14a-f to give ethyl 2-pyrazoline-5-carboxylate derivatives 15,16. Also, cycloaddition of 3,4 to 3-cyanocoumarin 19a or 3-phenylsulphonylcoumarin 19b or 3-bromocoumarin 19c give chromeno [3,4-c]pyrazol-4(3H)-one derivatives 20. In the same direction, the cycloaddition of 3,4 to 3-acetylcoumarin 22 and 3-benzoylcoumarin 23 gives the corresponding dihydrochromeno[3,4-] pyrazol-4(3H)-one 24 and 25 respectively. Oxidation of 24 and 25 give 20. Most of the prepared compounds showed good to moderate antibacterial and antifungal activities.

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“…Pyrazole and its synthetic analogues have been found to exhibit industrial, agricultural and biological applications. [7][8][9][10][11] Pyrazoles are an interesting group of compounds many of which possess broad spectrum pharmacological properties, such as analgesic, antipyretic, antidepressant and antirheumatic 12,13 and are also well known for their pronounced anti-inflammatory activity 14 as well they are used as potent antidiabetic agents 15 . Moreover, pyrazoles have played a crucial part in the development of heterocyclic chemistry and used extensively as useful synthon in organic synthesis.…”

Section: Introductionmentioning

confidence: 99%

Synthetic and pharmacological studies on some 1-isonicotinoyl-3-methyl-4-(4-substituted phenyl)-3a,4-dihydro pyrazolo [3,4-c]pyrazoles and their ethoxyphthalimide derivatives

Ojha¹,

Bapna²,

Talesara³

2008

Arkivoc

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ChemInform Abstract: New Pyrazolo[3,4‐b]pyrazines: Synthesis and Biological Activity.

Cited by 34 publications

References 0 publications

Antibacterial, Antifungal, Anti-Oxidant, Anti-Inflammatory and Anti-Hypertensive Activities of N-Chloropyrazinamide

Antibacterial, Antifungal, Anti-Oxidant, Anti-Inflammatory and Anti-Hypertensive Activities of N-Chloropyrazinamide

Synthesis and antimicrobial evaluation of some new pyrazole, pyrazoline and chromeno[3,4-c]pyrazole derivatives

Synthetic and pharmacological studies on some 1-isonicotinoyl-3-methyl-4-(4-substituted phenyl)-3a,4-dihydro pyrazolo [3,4-c]pyrazoles and their ethoxyphthalimide derivatives

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