ChemInform Abstract: Inducamides A—C, Chlorinated Alkaloids from an RNA Polymerase Mutant Strain of Streptomyces sp.

Fu, Peng; Jamison, Matthew; La, Scott; MacMillan, John B.

doi:10.1002/chin.201518247

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2021

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“…This mutation modulate bacterial gene expression, including natural product biosynthetic pathways and yielded new alkaloids inducamide A-C (ref. 3).…”

Section: Introductionmentioning

confidence: 99%

A benzaldehyde derivative obtained from Hypoxylon truncatum NBRC 32353 treated with hygromycin B

et al. 2021

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The ribosome-targeted antifungal agent hygromycin B (HygB) alters the secondary metabolite profiles of fungi. Hypoxylon truncatum NBRC 32353 fermented in the presence of hygromycin B in barley medium activated secondary metabolite synthesis. A new benzaldehyde derivative truncaaldehyde (1) was obtained, along with thirteen known compounds (2-14). The structures of the new compounds were revealed using NMR and single-crystal X-ray crystallography. The total synthesis of (±)-1 was achieved using a four-step sequence, and chiral separation was accomplished. The isolated compounds were tested for their monoamine oxidase (MAO) -A and -B inhibitory activities, with six compounds ((±)-1, 4, 5, 7, 8 and 10) showing inhibitory activity.

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“…This mutation modulate bacterial gene expression, including natural product biosynthetic pathways and yielded new alkaloids inducamide A-C (ref. 3).…”

Section: Introductionmentioning

confidence: 99%