Homooligopeptides containing a,a-diethylgycine ( 2-amino-2-ethylbutanoic acid), were synthesized by conventional solution methods. An ethyl or methyl ester was used as protecting group at the C-terminus and a trifluoroacetyl group as protecting group at the N-terminus of the peptides. The conformations of such tri-, penta-, and hexapeptides in the solid state were studied using X-ray crystallographic analysis, and were shown to be a bent planar C5-conformation in the case of tripeptide 8a, and a 3 10 -helical…
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