ChemInform Abstract: Facile C—H Bond Activation for Deuterium and Tritium Labeling of Glycoconjugates Conducted in Ultrasonic and Microwave Fields

Bokatzian-Johnson, S. S.; Maier, M. L.; Bell, R. H.; Alston, K. E.; Le, B. Y.; Cioffi, Eugene A.

doi:10.1002/chin.200838248

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“…A series of fluorobenzophenones, 1-( Two notable reviews on tritiation methodology appeared, one on current developments, 28 and another which focuses on C-H bond activation for 2H/3H labeling of glycoconjugates using ultrasonic and microwave activation. 29 A series of H/D exchange reactions was reported using hydride-activated catalysts. A number of safe, user friendly and efficient methods for deuterium incorporation are highlighted, with applications in the form of bi and tricyclic aromatic compounds and chiral natural products including dextrorphan 47 and formoterol 48.…”

Section: History Of Microwaves In Pet Labelingmentioning

confidence: 99%

Microwave-accelerated transformations in synthetic organic & medicinal chemistry

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Microwave assisted organic syntheses have evolved from pioneering work conducted in the 1980's to become a central feature of contemporary organic chemistry. Though initial research was conducted using modified domestic instruments, a variety of sophisticated reactors are now available, and the technology has been adopted widely throughout the pharmaceutical industry. Based on dielectric heating, microwave mediated synthetic transformations exploit the ability to achieve very carefully controlled yet rapid application of thermal energy, which typically results in faster reaction rates and improved product impurity profiles. The research described herein highlights powerful new applications of microwave assisted organic synthesis with particular emphasis on radiolabeling methodologies. In this arena, the full benefits of fast reaction rates are exploited as the methodology can allow practical routes to short half-life radiopharmaceuticals otherwise inaccessible by conventional means. Following a

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Section: History Of Microwaves In Pet Labelingmentioning

confidence: 99%

Microwave-accelerated transformations in synthetic organic & medicinal chemistry

Kallmerten¹

View full text Add to dashboard Cite

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ChemInform Abstract: Facile C—H Bond Activation for Deuterium and Tritium Labeling of Glycoconjugates Conducted in Ultrasonic and Microwave Fields

Cited by 1 publication

References 1 publication

Microwave-accelerated transformations in synthetic organic & medicinal chemistry

Microwave-accelerated transformations in synthetic organic & medicinal chemistry

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