ChemInform Abstract: EPSP Synthase: The Design and Synthesis of Bisubstrate Inhibitors Incorporating Novel 3‐Phosphate Mimics

Abstract

MILLER, M. J.; BRACCOLINO, D. S.; CLEARY, D. G.; COREY, S. D.; FONT, J. L.; GRUYS, K. J.; HAN, C. Y.; LIN, K.-C.; PANSEGRAU, P. D.; REAM, J. E.; SCHNUR, D.; SHAH, A.; WALKER, M. C.; Phosphorus, Sulfur Silicon Relat. Elem. 76 (1993) 1-4, 115-118; Struct. Med. Chem. Sect., Corp. Res. Group, Monsanto Co., St. Louis, MO 63198, USA; EN)

A new family of sulfamidophosphonates derivatives: Microwave-accelerated multicomponent synthesis, characterization and X-Ray Crystallographic Study.

“…Especially, α-aminophosphonates compounds exhibit excellent therapeutic and pharmaceutical properties [10][11][12][13][14][15][16][17][18][19][20] , due to their isosteres with α-amino acids [21][22] such anticancer drugs [23][24] , haptens of catalytic antibodies [25][26] , antifungals 27 , anti-HIV agents 28 , enzymes inhibitors 29 , antiviral [30][31] , antiin ammatory 32 , anti-Alzheimer 33 , antioxidant 34 antimalarial 35 and inhibition of carbonic anhydrase [36][37] . The importance of the α-aminophosphonates is illustrated by the publications of several reviews per years [38][39] .…”