Abstract:Design, Synthesis and Antibacterial Activity of Novel Ketolides Bearing an Aryltetrazolyl-Substituted Alkyl Side Chain. -A series of novel C-11,12 cyclic carbamate ketolides (17 examples) are synthesized from clarithromycin and evaluated for their antibacterial activities. Derivatives (I), the most active compound, exhibits excellent antibacterial potency against all the strains studied. -(SONG, Q.-L.; GUO, B.-Q.; ZHANG, W.; LAN, P.; SUN, P.-H.; CHEN*, W.-M.; J. Antibiot. 64 (2011) 8, 571-581, http://dx.doi.or… Show more
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