ChemInform Abstract: DAST‐Mediated Cyclization of α,α‐Disubstituted‐α‐acylaminoketones: Efficient and Divergent Synthesis of Unprecedented Heterocycles.

Abstract

DAST-Mediated Cyclization of α,α-Disubstituted-α-acylaminoketones: Efficient and Divergent Synthesis of Unprecedented Heterocycles. -The title reaction affords a broad spectrum of fluorooxazoline products. As is shown for derivative (IVa), they can be used for further transformation to different types of heterocyclic frameworks. -(BIGOT, A.; BLYTHE, J.; PANDYA, C.; WAGNER, T.; LOISELEUR*, O.; Org. Lett. 13 (2011) 2, 192-195, http://dx.doi.org/10.1021/ol102454e ; Res. Chem., Syngenta Crop Prot. Muenchwilen AG, CH-4332 Stein, Switz.; Eng.) -R. Simon 16-122