ChemInform Abstract: Convenient Synthesis of Benzo‐Fluorinated Dibenz[b,f]azepines: Rearrangements of Isatins, Acridines, and Indoles.

Abstract

Convenient Synthesis of Benzo-Fluorinated Dibenz[b,f]azepines: Rearrangements of Isatins, Acridines, and Indoles. -The direct fluorination of dibenzazepines with SelectFluor fails. A 5-step synthesis based on isatin provides precursors such as (V) on a gram scale. Starting from indoles a range of regioisomeric fluorinated products (IX) and (X) is generated in 2 steps. -(ELLIOTT, E.-C.; BOWKETT, E. R.; MAGGS, J. L.; BACSA, J.; PARK, B. K.; REGAN, S. L.; O'NEILL, P. M.; STACHULSKI*, A. V.; Org. Lett. 13 (2011) 20, 5592-5595, http://dx.doi.org/10.1021/ol202318w ; Dep. Chem., Univ. Liverpool, Liverpool L69 7ZD, UK; Eng.) -H. Simon