Abstract:Aryl Rings Are Part of the Darpone Pharmacophore.-In order to investigate structure-activity relationships in the antiproliferative darpone series, the derivatives (VI) and (VIII) are synthesized and evaluated for cancer cell growth inhibition. Since both (VI) and (VIII) are devoid of noteworthy antiproliferative activity, both aryl substituents can be considered as part of the darpone pharmacophore.
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