ChemInform Abstract: An Easy Entry to Optically Active Spiroindolinones: Chiral Broensted Acid Catalyzed Pictet—Spengler Reactions of Isatins.

Abstract

An Easy Entry to Optically Active Spiroindolinones: Chiral Broensted Acid Catalyzed Pictet-Spengler Reactions of Isatins. -Both enantiomers of the catalyst are applied. The reaction tolerates traces of moisture, thus making the method more practicable for the synthesis of biologically active compounds, bearing a core of the antimalarial agents. -(DUCE, S.; PESCIAIOLI, F.; GRAMIGNA, L.; BERNARDI*, L.; MAZZANTI, A.; RICCI, A.; BARTOLI, G.; BENCIVENNI, G.; Adv. Synth. Catal. 353 (2011) 6, 860-864, http://dx.doi.org/10.1002/adsc.201100050 ; Dip. Chim. Org. "A. Mangini", Univ. Bologna, I-40126 Bologna, Italy; Eng.) -Y. Steudel 36-156