ChemInform Abstract: Aminoalkyltetrazoles. Part 5. Synthesis and Properties of N‐(β‐5‐Tetrazolylethyhaminoacetic Acid.

Multifunctional Amino Acid Derivative Coordination Compounds: Novel Contrast Agent and Luminescence Materials

“…Compounds ZnÀ L_tyr (6) and ZnÀ D_ tyr (7) display a set of bands located at 180, 186, 191, 202, 236 and 287 nm. Finally, Compounds CdÀ L_tyr (8) and Cd-D_tyr (9) exhibit three main bands at 183, 213 and 230 nm, with alternating Cotton effects for all previously described compounds (4-9). Note that, despite the isostructural nature of compounds ZnÀ L_tyr (6) and ZnÀ D_tyr (7) concerning CdÀ L_tyr (8) and CdÀ D_tyr (9) CD spectra exhibit slightly different shape which is due to the data collection parameters.…”

“…Nonetheless, the maxima peak at a similar wavelength. In all cases, CD absorption bands are present in the corresponding UV-Vis spectra in compounds (2)(3)(4)(5)(6)(7)(8)(9).…”

“…Among in situ synthesised ligands, Demko-Sharpeless [2 + 3] cycloaddition reaction [3][4][5] is presented as an easy-handling alternative for the synthesis of tetrazole derivate ligands by reaction of organonitriles with metal azides (Scheme S1 in the ESI), [6,7] as for instance in the synthesis of [ [2-(5tetrazolyl)ethyl]amino]acetic acid. [8] In this work, our main goal will be the synthesis of novel luminescent chiral in situ generated tetrazole-derivative amino acid based coordination compounds as novel imaging agents. In situ synthesised coordination compounds will derive by the cycloaddition of cyanoethylated amino acids with sodium azide according to the procedure described by Demko-Sharpeless.…”

“…Generally, for the synthesis of coordination compounds with extended dimensionality, solvothermal routes have allowed featuring chemical reactions at high temperature and pressure conditions yielding crystalline coordination complexes. Among in situ synthesised ligands, Demko‐Sharpeless [2+3] cycloaddition reaction [3–5] is presented as an easy‐handling alternative for the synthesis of tetrazole derivate ligands by reaction of organonitriles with metal azides (Scheme S1 in the ESI), [6,7] as for instance in the synthesis of [[2‐(5‐tetrazolyl)ethyl]amino]acetic acid [8] …”