Alexandros Zografos, Christos Mitsos, Olga Igglessi-Markopoulou
A Tandem C-Acylation-Cyclization Reaction Sequence for the Synthesis of New N-Acyl-3-Substituted-1,8-naphthyridine-2,4-diones.-Base-promoted condensation of the pyrido oxazinones (I) with active methylene compounds (II) yields 1,8-naphthyridine-2,4-diones (III). In certain cases such as (V), the C-acylation key intermediates can be isolated and subsequently cyclized.
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