ChemInform Abstract: A New Nonpeptide Tachykinin NK<sub>1</sub> Receptor Antagonist Isolated from the Plants of Compositae.

Yamamoto, Atsushi; Nakamura, Ko; Furukawa, K.; Konishi, Yoko; Ogino, Takashi; Higashiura, Kunihiko; Yago, Hisashi; Okamoto, Kaoru; Otsuka, Masanori

doi:10.1002/chin.200229232

Cited by 1 publication

(1 citation statement)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, several previously known compounds were identified by HR-ESI-MS, 1D, and 2D NMR data as well as by comparison with literature data and authentic standards. They include arglabin (a guaianolide) ( 3 ) 15 , 20 , 3 β -hydroxycostunolide (a germacranolide) ( 4 ) 21 , isocostic acid (an eudesmane) ( 5 ) 22 , tetracoumaroyl spermine ( 8 ) 23 , 24 , chlorogenic acid ( 9 ) 25 , 3,5-diCQA ( 10 ), 3,5-diCQA methyl ester ( 11 ) 26 , 3,4-diCQA ( 12 ) 27 , and tryptophan ( 13 ) ( Fig. 2 ).…”

Section: Resultsmentioning

confidence: 99%

New Guaianolide Sesquiterpene Lactones and Other Constituents from Pyrethrum pulchrum

et al. 2021

View full text Add to dashboard Cite

Pyrethrum pulchrum is a rare Mongolian plant species that has been traditionally used as an ingredient in various remedies. Bioactivity-guided fractionation performed on the methanol extract of its aerial parts led to the isolation of 2 previously undescribed guaianolide-type sesquiterpene lactones, namely 1β,10β-epoxy-8α-hydroxyguaia-3,11(13)-dien-6,12-olide (1) and 1,8,10-trihydroxyguaia-3,11(13)-dien-6,12-olide (2), along with the isolation or chromatographic identification of 11 compounds, arglabin (3), 3β-hydroxycostunolide (4), isocostic acid (5), (E)-9-(2-thienyl)-6-nonen-8-yn-3-ol (6), (Z)-9-(2-thienyl)-6-nonen-8-yn-3-ol (7), N 1,N 5,N 10,N 14-tetra-p-coumaroyl spermine (8), chlorogenic acid (9), 3,5-di-O-caffeoylquinic acid (10), 3,5-di-O-caffeoylquinic acid methyl ester (11), 3,4-di-O-caffeoylquinic acid (12), and tryptophan (13). Their structures were assigned based on spectroscopic and spectrometric data. The antimicrobial, antiproliferative and cytotoxic activities of selected compounds were evaluated. The new compounds showed weak to moderate antimicrobial activity. Arglabin (3), the major sesquiterpene lactone found in the methanol extract of P. pulchrum, exhibited the highest activity against human cancer lines, while compound 1 also possesses significant antiproliferative activity against leukemia cells.

show abstract

Section: Resultsmentioning

confidence: 99%

New Guaianolide Sesquiterpene Lactones and Other Constituents from Pyrethrum pulchrum

et al. 2021

View full text Add to dashboard Cite

show abstract

ChemInform Abstract: A New Nonpeptide Tachykinin NK₁ Receptor Antagonist Isolated from the Plants of Compositae.

Cited by 1 publication

References 1 publication

New Guaianolide Sesquiterpene Lactones and Other Constituents from Pyrethrum pulchrum

New Guaianolide Sesquiterpene Lactones and Other Constituents from Pyrethrum pulchrum

Contact Info

Product

Resources

About

ChemInform Abstract: A New Nonpeptide Tachykinin NK1 Receptor Antagonist Isolated from the Plants of Compositae.

Cited by 1 publication

References 1 publication

New Guaianolide Sesquiterpene Lactones and Other Constituents from Pyrethrum pulchrum

New Guaianolide Sesquiterpene Lactones and Other Constituents from Pyrethrum pulchrum

Contact Info

Product

Resources

About

ChemInform Abstract: A New Nonpeptide Tachykinin NK₁ Receptor Antagonist Isolated from the Plants of Compositae.