ChemInform Abstract: A Conformationally Restrained Series of AT1‐Selective Angiotensin II Antagonists.

Abstract

A Conformationally Restrained Series of AT1-Selective Angiotensin II Antagonists.-The desired target compounds (VI) are restrained analogues of known AII receptor antagonists. The optimal products are the dihydroindanyl derivatives (a series). -(CARPINO, P. A.; SNEDDON, S. F.; DA SILVA JARDINE, P.; MAGNUS-AYRITEY, G. T.; RAUCH, A. L.; BURKARD, M. R.; Bioorg. Med. Chem. Lett. 4 (1994) 1, 93-98; Dep. Med.

The Directed Ortho Metallation (DoM)–Cross‐Coupling Nexus. Synthetic Methodology for the Formation of Aryl–Aryl and Aryl–Heteroatom–Aryl Bonds

“…Benzonitriles are converted into aryltetrazoles, hence the connection between 121 and 125 [138]. Higher substituted derivatives of the prototype compound 121 may be available by an in situ DoM silylation-ipso-halodesilylation method [28].…”