Chemically robust succinimide-group-assisted irreversible bonding of poly(dimethylsiloxane)–thermoplastic microfluidic devices at room temperature

Sivakumar, R.; Lee, Nae Yoon

doi:10.1039/d0an01268h

Cited by 13 publications

(22 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Borysiak et al reported maximum pressures of 4.1 bar without failure for bonding of SEBS to itself, PS, or glass surfaces applying 75 • C for 30 min [26]. When compared to PDMS bonded to itself [41], glass [42], or thermoplastics [43][44][45], similar or even higher values of bonding strength can be achieved using our presented TPE-based approach (Table 1), even after 7 days of exposure to buffer. Preventing the absorption of molecules from the solution into the bulk materials of the chips is of upmost importance due to the high surface-to-volume ratios seen in microfluidic systems, which can lead to the rapid drop of concentrations in the perfused solution [46].…”

Section: Device Bonding Strategiesmentioning

confidence: 53%

“…Borysiak et al reported maximum pressures of 4.1 bar without failure for bonding of SEBS to itself, PS, or glass surfaces applying 75 °C for 30 min [ 26 ]. When compared to PDMS bonded to itself [ 41 ], glass [ 42 ], or thermoplastics [ 43 , 44 , 45 ], similar or even higher values of bonding strength can be achieved using our presented TPE-based approach ( Table 1 ), even after 7 days of exposure to buffer.…”

Section: Resultsmentioning

confidence: 92%

See 1 more Smart Citation

Facile Patterning of Thermoplastic Elastomers and Robust Bonding to Glass and Thermoplastics for Microfluidic Cell Culture and Organ-on-Chip

et al. 2021

View full text Add to dashboard Cite

The emergence and spread of microfluidics over the last decades relied almost exclusively on the elastomer polydimethylsiloxane (PDMS). The main reason for the success of PDMS in the field of microfluidic research is its suitability for rapid prototyping and simple bonding methods. PDMS allows for precise microstructuring by replica molding and bonding to different substrates through various established strategies. However, large-scale production and commercialization efforts are hindered by the low scalability of PDMS-based chip fabrication and high material costs. Furthermore, fundamental limitations of PDMS, such as small molecule absorption and high water evaporation, have resulted in a shift toward PDMS-free systems. Thermoplastic elastomers (TPE) are a promising alternative, combining properties from both thermoplastic materials and elastomers. Here, we present a rapid and scalable fabrication method for microfluidic systems based on a polycarbonate (PC) and TPE hybrid material. Microstructured PC/TPE-hybrid modules are generated by hot embossing precise features into the TPE while simultaneously fusing the flexible TPE to a rigid thermoplastic layer through thermal fusion bonding. Compared to TPE alone, the resulting, more rigid composite material improves device handling while maintaining the key advantages of TPE. In a fast and simple process, the PC/TPE-hybrid can be bonded to several types of thermoplastics as well as glass substrates. The resulting bond strength withstands at least 7.5 bar of applied pressure, even after seven days of exposure to a high-temperature and humid environment, which makes the PC/TPE-hybrid suitable for most microfluidic applications. Furthermore, we demonstrate that the PC/TPE-hybrid features low absorption of small molecules while being biocompatible, making it a suitable material for microfluidic biotechnological applications.

show abstract

Section: Device Bonding Strategiesmentioning

confidence: 53%

Section: Resultsmentioning

confidence: 92%

Facile Patterning of Thermoplastic Elastomers and Robust Bonding to Glass and Thermoplastics for Microfluidic Cell Culture and Organ-on-Chip

et al. 2021

View full text Add to dashboard Cite

show abstract

“…After bonding the PDMS with the substrates, the assembly is pulled apart. Although this pull test is performed in several works (e.g., by the team of Nae Yoon Lee [43][44][45][46][47]), it might have some drawbacks. Although cohesive failures can be easily distinguished from adhesive failures, the tensile strength cannot be adequately calculated in the latter case.…”

Section: Tensile Strength Measurementsmentioning

confidence: 99%

“…For the sake of better comparability between different structures/geometries, besides the absolute maximum flow rates (expressed in mL/min), the ratio of the liquid volume that flows through the channel within 1 min and the channel volume is also frequently given (expressed as flow-volume/channelvolume/min). Without a doubt, this is one of the most widespread methods for testing microchannel functionality [19,35,36,38,[43][44][45][46][47]56,57].…”

Section: Leakage Testmentioning

confidence: 99%

See 1 more Smart Citation

PDMS Bonding Technologies for Microfluidic Applications: A Review

2021

View full text Add to dashboard Cite

This review summarizes and compares the available surface treatment and bonding techniques (e.g., corona triggered surface activation, oxygen plasma surface activation, chemical gluing, and mixed techniques) and quality/bond-strength testing methods (e.g., pulling test, shear test, peel test, leakage test) for bonding PDMS (polydimethylsiloxane) with other materials, such as PDMS, glass, silicon, PET (polyethylene terephthalate), PI (polyimide), PMMA (poly(methyl methacrylate)), PVC (polyvinyl chloride), PC (polycarbonate), COC (cyclic olefin copolymer), PS (polystyrene) and PEN (polyethylene naphthalate). The optimized process parameters for the best achievable bond strengths are collected for each substrate, and the advantages and disadvantages of each method are discussed in detail.

show abstract

Functional PDMS Elastomers: Bulk Composites, Surface Engineering, and Precision Fabrication

Li,

Zhang,

et al. 2023

Advanced Science

View full text Add to dashboard Cite

Polydimethylsiloxane (PDMS)—the simplest and most common silicone compound—exemplifies the central characteristics of its class and has attracted tremendous research attention. The development of PDMS‐based materials is a vivid reflection of the modern industry. In recent years, PDMS has stood out as the material of choice for various emerging technologies. The rapid improvement in bulk modification strategies and multifunctional surfaces has enabled a whole new generation of PDMS‐based materials and devices, facilitating, and even transforming enormous applications, including flexible electronics, superwetting surfaces, soft actuators, wearable and implantable sensors, biomedicals, and autonomous robotics. This paper reviews the latest advances in the field of PDMS‐based functional materials, with a focus on the added functionality and their use as programmable materials for smart devices. Recent breakthroughs regarding instant crosslinking and additive manufacturing are featured, and exciting opportunities for future research are highlighted. This review provides a quick entrance to this rapidly evolving field and will help guide the rational design of next‐generation soft materials and devices.

show abstract

Chemically robust succinimide-group-assisted irreversible bonding of poly(dimethylsiloxane)–thermoplastic microfluidic devices at room temperature

Abstract: This study investigates surface chemical modification using anhydride silane and amino silane reagents at room temperature (RT) to realize bonding between silicon-based PDMS and non-silicon thermoplastics. The anhydride silane has...

Cited by 13 publications

References 39 publications

Facile Patterning of Thermoplastic Elastomers and Robust Bonding to Glass and Thermoplastics for Microfluidic Cell Culture and Organ-on-Chip

Facile Patterning of Thermoplastic Elastomers and Robust Bonding to Glass and Thermoplastics for Microfluidic Cell Culture and Organ-on-Chip

PDMS Bonding Technologies for Microfluidic Applications: A Review

Functional PDMS Elastomers: Bulk Composites, Surface Engineering, and Precision Fabrication

Contact Info

Product

Resources

About