Chemically modified xanthan and gellan for preparation of biomaterials for ophthalmic applications

Hamcerencu, Mihaela; Popa, Marcel; Riess, Gérard; Desbrières, Jacques

doi:10.1002/pi.5927

Cited by 8 publications

(6 citation statements)

References 40 publications

(41 reference statements)

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“…The study evidently confirms the increase in stability of xanthan gum in different phase. Formation of inter penetrating networks was found to be the reason for improved mechanical strength and ultimately contributing to the stability of formulation (Hamcerencu et al, 2019;Kulkarni et al, 2019).…”

Section: Grafting With Acryl Acidmentioning

confidence: 97%

“…This substitution of hydroxyl group is known as etherification and is basically the process of dehydration of hydroxyl group when polysaccharide reacted with carboxymethyl group. For the customization of the release profile and enhance the mucoadhessive property of the xanthan gum, carboxymethylation is done (Hamcerencu, Popa, Riess & Desbrieres, 2019).…”

Section: Etherification Of Xanthan Gummentioning

confidence: 99%

“…The grafting of natural polysaccharides with the help of enzyme has been used in large number of industries. Certain organic chemicals used for the grafting of xanthan gum are maleic anhydride, acrylic acid and acryloyl chloride (Hamcerencu et al, 2019;Kulkarni et al, 2019).…”

Section: Grafting Of Xanthan Gummentioning

confidence: 99%

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Pharmaceutical Applications of Xanthan Gum in Ophthalmic Delivery Systems

Bhatia

Kumar

Batra

et al. 2020

JPTRM

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Introduction: Ophthalmic delivery system is one of the challenging domains of formulation and development due to tear dilutions, drug loss due to lacrimal drainage, limited volume and pre-corneal barriers. Several pharmaceutical technologies are exploited in order to counter the challenges posed by ocular route such as emulsions and suspensions. But all these technologies have stability issues which lead to their limited use.Background: Among polysaccharides, xanthan gum, a natural occurring biodegradable exopolysaccharide extracted from bacterium Xanthomonas campestris is widely accepted as one of the potential polysaccharide in ophthalmic.Review Results: Xanthan gum is commonly used as an additive to various ophthalmic formulations due to its mucoadhesive property and imparting stability to various novel pharmaceutical technologies for ophthalmic. Xanthan gum also allows chemical modifications with various ligands which consequently allow controlled release, modified dissolution rate and viscoelasticity. Conclusion: In this review we are providing an insight over potential of pharmaceutical applications of xanthan gum. Also, we have discussed the scope of chemical modifications in xanthan gum with modified physicochemical properties.

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Section: Grafting With Acryl Acidmentioning

confidence: 97%

Section: Etherification Of Xanthan Gummentioning

confidence: 99%

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Pharmaceutical Applications of Xanthan Gum in Ophthalmic Delivery Systems

Bhatia

Kumar

Batra

et al. 2020

JPTRM

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“…Xanthan gum is a negatively charged polysaccharide with interesting rheological and gelling characteristics, and it was proposed for ophthalmic applications such as sustained drug release [133,134]. This polymer is also used as an additive to increase the drug release time in comparison to conventional eye drops [135].…”

Section: Other Polysaccharidesmentioning

confidence: 99%

Regulation of the Ocular Cell/Tissue Response by Implantable Biomaterials and Drug Delivery Systems

Baino

Kargozar

2020

Bioengineering

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Therapeutic advancements in the treatment of various ocular diseases is often linked to the development of efficient drug delivery systems (DDSs), which would allow a sustained release while maintaining therapeutic drug levels in the target tissues. In this way, ocular tissue/cell response can be properly modulated and designed in order to produce a therapeutic effect. An ideal ocular DDS should encapsulate and release the appropriate drug concentration to the target tissue (therapeutic but non-toxic level) while preserving drug functionality. Furthermore, a constant release is usually preferred, keeping the initial burst to a minimum. Different materials are used, modified, and combined in order to achieve a sustained drug release in both the anterior and posterior segments of the eye. After giving a picture of the different strategies adopted for ocular drug release, this review article provides an overview of the biomaterials that are used as drug carriers in the eye, including micro- and nanospheres, liposomes, hydrogels, and multi-material implants; the advantages and limitations of these DDSs are discussed in reference to the major ocular applications.

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“…Stiff polysaccharides are of particular interest, since they can form networks with rather high viscoelasticity at very low polymer concentrations (around 0.05-0.1%) [6]. Due to this, they are widely used as thickeners in various industrial applications, e.g., in the production of consumer goods and food industry [7,8], materials for biomedical applications [9,10] etc. Their distinct application is the preparation of fracturing fluids for oil industry [11].…”

Section: Introductionmentioning

confidence: 99%

pH-Dependent Gelation of a Stiff Anionic Polysaccharide in the Presence of Metal Ions

et al. 2020

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Cross-linking of polysaccharides by metal ions provides polymer gels highly required by industrial applications. In this article, we study the rheological properties and microstructure of solutions of a stiff anionic polysaccharide xanthan cross-linked by chromium (III) ions, and we demonstrate that their properties are highly sensitive to the preparation pH. Stable gels are obtained in a wide range of pH from 2.4 to 7.8. The maximum elastic modulus is observed for the gels made at pH 6.3, and by freeze-fracture transmission electron microscopy it is shown that they are characterized by the most dense network structure. However, out of this pH interval, no gelation is observed. At low pH (< 2.4) it is due to high protonation of carboxylic groups of xanthan preventing their interaction with chromium ions, and to the disappearance of oligomeric ions, which are effective in cross-linking. At high pH (> 7.8) the absence of gelation is caused by the transformation of reactive chromium ions into insoluble chromium hydroxide. At the same time, for the gels initially formed at pH 6.3, subsequent change of pH to strongly acidic (1.4) or basic (8.9) medium does not affect appreciably their properties, meaning that chromium cross-links are stable once they are formed. These observations open a reliable route to produce polysaccharide gels with required mechanical properties in a wide pH range where they initially cannot be prepared. It is also shown that the increase of pH to 6.3 of the initially ungelled solution prepared at pH 1.5 results in gelation. This effect offers a facile way for delayed gelation of polysaccharides, which is especially required by oil industry.

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Chemically modified xanthan and gellan for preparation of biomaterials for ophthalmic applications

Cited by 8 publications

References 40 publications

Pharmaceutical Applications of Xanthan Gum in Ophthalmic Delivery Systems

Pharmaceutical Applications of Xanthan Gum in Ophthalmic Delivery Systems

Regulation of the Ocular Cell/Tissue Response by Implantable Biomaterials and Drug Delivery Systems

pH-Dependent Gelation of a Stiff Anionic Polysaccharide in the Presence of Metal Ions

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