Chemically modified polyacrylamide-g-guar gum-based crosslinked anionic microgels as pH-sensitive drug delivery systems: preparation and characterization

Soppimath, Kumaresh S.; Kulkarni, Akshay; Aminabhavi, Tejraj M.

doi:10.1016/s0168-3659(01)00404-7

Cited by 248 publications

(97 citation statements)

References 22 publications

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“…Of these, GG is a non-ionic plant polysaccharide having many advantages such as low cost, widespread availability, and biodegradability. GGbased controlled release (CR) formulations have been widely explored in clinical trials (10,11). On the other hand, PNIPAAm is a thermotropic polymer exhibiting lower critical solution temperature (LCST) and hydrogels containing NIPAAm swells in aqueous media at a temperature lower than 32°C due to the formation hydrogen bond between water molecules and the hydrophilic -CONH-groups of the polymer side chains.…”

Section: Introductionmentioning

confidence: 99%

Novel pH- and Temperature-Responsive Blend Hydrogel Microspheres of Sodium Alginate and PNIPAAm-g-GG for Controlled Release of Isoniazid

2012

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Abstract. This paper reports the preparation and characterization of novel pH-and thermo-responsive blend hydrogel microspheres of sodium alginate (NaAlg) and poly(N-isopropylacrylamide)(PNIPAAm)-grafted-guar gum (GG) i.e., PNIPAAm-g-GG by emulsion cross-linking method using glutaraldehyde (GA) as a cross-linker. Isoniazid (INZ) was chosen as the model antituberculosis drug to achieve encapsulation up to 62%. INZ has a plasma half-life of 1.5 h, whose release was extended up to 12 h. Fourier transform infrared spectroscopy was used to confirm the grafting reaction and chemical stability of INZ during the encapsulation. Differential scanning calorimetry was used to investigate the drug's physical state, while powder X-ray diffraction confirmed the molecular level dispersion of INZ in the matrix. Scanning electron microscopy confirmed varying surface morphologies of the drug-loaded microspheres. Temperature-and pH-responsive nature of the blend hydrogel microspheres were investigated by equilibrium swelling, and in vitro release experiments were performed in pH1.2 and pH7.4 buffer media at 37°C as well as at 25°C. Kinetics of INZ release was analyzed by Ritger-Peppas empirical equation to compute the diffusional exponent parameter (n), whose value ranged between 0.27 and 0.58, indicating the release of INZ follows a diffusion swelling controlled release mechanism.

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Section: Introductionmentioning

confidence: 99%

Novel pH- and Temperature-Responsive Blend Hydrogel Microspheres of Sodium Alginate and PNIPAAm-g-GG for Controlled Release of Isoniazid

2012

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“…The packing properties of the material can be evaluated by the bulk and tapped density. The bulk density and tapped density were 0.43±0.01 to 0.47±0.02 gm/mL and 0.50±0.015 to 0.54±0.02 gm/mL, respectively, which indicate good flowability of the granules (Soppimath et al, 2001) Carr's index was found to be 12.48±0.27 to 12.89±0.14 and Hausner's ratio 1.13±0.022 to 1.17±0.010 the above results indicates that the granules formed were easily compressible.…”

Section: Resultsmentioning

confidence: 89%

Effect of HPMC and ethyl cellulose polymeric granules and its combinations in press coated tablets of lornoxicam: fabrication and in vitro characterization

Dineshmohan¹,

Gupta

Alluri³

et al. 2015

Int Curr Pharm J

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The main objective of the present exploration was to formulate and evaluate chronomodulated press-coated tablets to deliver the NSAID lornoxicam, when a pain in the joints, functional disability persist in the early morning time is typically observed in most Rheumatoid arthritis (RA) patients. Pre formulation studies and drug excipient compatibility studies were carried out for lornoxicam and excipients. Core tablets containing lornoxicam was prepared by direct compression method and the tablets were subjected to various pre-compression and post-compression parameters (C1-C4 formula) based on the above result best core tablet batch was selected and used for press coating processes. HPMC and EC granules were used as controlled release polymers in the outer layer. These tablets were subjected to pre and post compression parameters, finally the tablets were evaluated for lag time and in vitro dissolution. Results of preformulation studies were acceptable limits. No interaction was observed between lornoxicam and excipients by FTIR. The results of pre and post compression studies were within limits. Formulation code CC3 was identified as best formulation that extends a release profile with 6 h lag time followed by complete lornoxicam release after 8 h. From the graphical representation it can be well perceive that this is perfectly fit in to Korsemeyer which had a Regression coefficient (R2) of 0.9431. The results of the in-vitro release data of this layer were fitted to the Korsemeyer-Peppas equation to examine the release pattern of the drug from the polymeric system. The drug release was identified as super case II transport as the n value found to be more than 0.89.Dineshmohan et al., International Current Pharmaceutical Journal, September 2015, 4(10): 447-452

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“…Soppimath et al 109 prepared spherical crosslinked hydrogels of polyacrylamide-grafted guar gum by emulsification. These were derivatized by saponification of -CONH 2 to -CO 2 H groups.…”

Section: Galactomananns As a Component Of Hydrogelsmentioning

confidence: 99%

Pharmaceutical use of galactomannans

Silveira¹,

Bresolin²

2011

Quím. Nova

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Recebido em 5/1/10; aceito em 13/8/10; publicado na web em 26/11/10 PHARMACEUTICAL USE OF GALACTOMANNANS. The pharmaceutical use of galactomannans from different sources, commercial and noncommercial, has been extensively studied over the past decade. Galactomannans show potential in the global trend towards the use of more plant-based products for ecological motives, and their production and application do not cause pollution or disturb the ecosystem. There is a variety of galactomannan sources and various pharmaceutical forms of application, such as tablets or capsules, hydrogels and films. Besides the simple use as inert excipient this polysaccharides play role in the modification of drug release, especially in colonic environmental, as a matrix or coating material.

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Chemically modified polyacrylamide-g-guar gum-based crosslinked anionic microgels as pH-sensitive drug delivery systems: preparation and characterization

Cited by 248 publications

References 22 publications

Novel pH- and Temperature-Responsive Blend Hydrogel Microspheres of Sodium Alginate and PNIPAAm-g-GG for Controlled Release of Isoniazid

Novel pH- and Temperature-Responsive Blend Hydrogel Microspheres of Sodium Alginate and PNIPAAm-g-GG for Controlled Release of Isoniazid

Effect of HPMC and ethyl cellulose polymeric granules and its combinations in press coated tablets of lornoxicam: fabrication and in vitro characterization

Pharmaceutical use of galactomannans

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